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are mTOR inhibitors and SIRT1 activators pro-depressogenic

depression anhedonia mtor sirt1 sirt mood plasticity

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#1 MankindRising

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Posted 07 March 2019 - 07:38 PM


So I started eating 500gram worth of grapes about 18 days ago roughly.

The first 5 days were amazing, I felt extremely good, the days after (up till day 12-14), the mood somewhat was less than the first 5 days but still very much got a relieve from depression.

However the effect seems to have backfired and Im now becoming more depressed and anhedonic.

 

SIRT1 can increase MAO-A expression and also be pro-depressive.

 

 

SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive.

https://www.ncbi.nlm...les/PMC3443638/

 

 

 

SIRT1 Mediates Depression-Like Behaviors in the Nucleus Accumbens

https://www.ncbi.nlm...les/PMC4978803/

 

 

 

Adversity in childhood and depression: linked through SIRT1

https://www.nature.c...icles/tp2015125

 

 

 

SIRT1 in neurodevelopment and brain senescence

https://www.ncbi.nlm...les/PMC4040287/

 

 

 

Obviously resveratrol also induces autophagy and mTOR inhibition and we know that antidepressants such as ketamine work through mTOR.

Is autophagy only beneficial for short term for depression? After all too much autophagy would block growth of new synapstic connections too much and give the net result of becoming even more depressed?

 

For all it matters the first few days felt as complete relieve from bad experiences from the past and life felt a fresh start so to speak, my guess is I should have stopped after day 5.

 

Any ideas on this? There quite a few people noticing weird antidepressant like qualities of resveratrol and even people that say it makes them feel crap after a few days.


Edited by MankindRising, 07 March 2019 - 07:39 PM.


#2 Oinen

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Posted 26 March 2019 - 01:52 AM

There isn't enough resveratrol in that amount of grapes to do anything I don't think. Even the red wine studies - the thing that the headlines left out was that you would have had to drink 500 bottles of red wine to get the amount of resveratrol used in the studies.

Resveratrol inhibits mTOR? I thought Rapamycin was the only way to do that, which is also insanely unsafe to do might I add, as Rapamycin suppresses the immune system to dangerous levels as it is used so that the body doesn't reject an organ transplant.

Anyways, whatever is causing this reaction is most likely not the grapes if I would have to guess.


Edited by Oinen, 26 March 2019 - 01:54 AM.


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Also tagged with one or more of these keywords: depression, anhedonia, mtor, sirt1, sirt, mood, plasticity

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