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a2a antagonist as safe-no tolerance stimulant

adenosine stimulant a2a tolerance

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#1 Painkillerrr

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Posted 29 March 2019 - 12:05 PM

Hello, i have not menaged to find any strong stimulant without tolerance. the only good target that i have found is adenosine 2a.


a2a antagonists are being tested as new parkinson treatment [1] and pretty much any parkinson drugs is a possible stimulant for healthy (l-dopa, mao inhibitors ecc.)


caffeine is a a2a antagonist, but its short-term effect and lack of selectivity (a1 antagonism cause tolernace overtime [2]) makes it pretty much useless for me.


teacrine seemed good, but it has no real stimulation and ruins my sleep (max 4-5 h while i take it in the morning)


[1] https://www.ncbi.nlm...les/PMC2583202/




studies: https://sci-hub.tw/1...1910-012-0279-2


is there someone who would like to do a small-group buy it buy any selective a2a antagonist??


the price should be low

Also tagged with one or more of these keywords: adenosine, stimulant, a2a, tolerance

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