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A ketogenic drink improves brain energy and some measures of cognition in mild cognitive impairment

acetoacetate alzheimers disease beta-hydroxybutyrate decanoic acid fluorodeoxyglucose glucose ketone medium chain triglyceride mild cognitive impairment octanoic acid

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#1 Engadin

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Posted 30 April 2019 - 06:46 PM


Highlights

 

• 30 g/day of medium chain triglyceride (kMCT) doubles brain ketone metabolism in MCI.
•As a result, net brain energy status improved on the kMCT.
•Improvement in some cognitive outcomes was positively related to brain ketone uptake.
•Both the kMCT and placebo were moderately well tolerated.

 

Abstract

 

Introduction

Unlike for glucose, uptake of the brain's main alternative fuel, ketones, remains normal in mild cognitive impairment (MCI). Ketogenic medium chain triglycerides(kMCTs) could improve cognition in MCI by providing the brain with more fuel.

 

Methods

Fifty-two subjects with MCI were blindly randomized to 30 g/day of kMCT or matching placebo. Brain ketone and glucose metabolism (quantified by positron emission tomography; primary outcome) and cognitive performance (secondary outcome) were assessed at baseline and 6 months later.

 

Results

Brain ketone metabolism increased by 230% for subjects on the kMCT (P < .001) whereas brain glucose uptake remained unchanged. Measures of episodic memory, language, executive function, and processing speed improved on the kMCT versus baseline. Increased brain ketone uptake was positively related to several cognitive measures. Seventy-five percent of participants completed the intervention.

 

Discussion

A dose of 30 g/day of kMCT taken for 6 months bypasses a significant part of the brain glucose deficit and improves several cognitive outcomes in MCI.

 

Source: https://www.scienced...552526019300111

 

 


Edited by Engadin, 30 April 2019 - 06:47 PM.

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#2 Heisok

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Posted 01 May 2019 - 04:54 PM

Interesting Engadin, thanks.

 

It was a 6 month study. They used 30 g/day of a 60% C8 ,40% C10 MCT oil mixed in lactose free skim milk.

 

They called it an emulsion, so the emulsification might play a role in absorption over simply pouring oil on ones food. (I do not know. Maybe use coffee :) ) That 30 gm dose should be around 2 tablespoons of oil. The authors indicate that a higher dose might work better. The 250 mL drink was supposed to be split evenly with 2 meals. Starting at 50 mL they were supposed to titrate up over 2 weeks. There appeared to be some tolerance issues as some on the active group dropped out. The authors indicate that the C8 is more "Ketogenic" so I wonder if using all C8 might work better, and if spreading the dose out during the day, and without the milk might make for greater tolerance and improvement. (Some claim that they have better tolerance for high purity C8 oil over a C8/C10 mix. )  I use 4 to 6 tablespoons of C8 spread out during the day, and have never had side effects.

 

Link to the full text:

 

https://www.research...tive_impairment

 


Edited by Heisok, 01 May 2019 - 04:55 PM.

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#3 Engadin

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Posted 02 May 2019 - 10:44 PM

Interesting Engadin, thanks.

 

It was a 6 month study. They used 30 g/day of a 60% C8 ,40% C10 MCT oil mixed in lactose free skim milk.

 

They called it an emulsion, so the emulsification might play a role in absorption over simply pouring oil on ones food. (I do not know. Maybe use coffee :) ) That 30 gm dose should be around 2 tablespoons of oil. The authors indicate that a higher dose might work better. The 250 mL drink was supposed to be split evenly with 2 meals. Starting at 50 mL they were supposed to titrate up over 2 weeks. There appeared to be some tolerance issues as some on the active group dropped out. The authors indicate that the C8 is more "Ketogenic" so I wonder if using all C8 might work better, and if spreading the dose out during the day, and without the milk might make for greater tolerance and improvement. (Some claim that they have better tolerance for high purity C8 oil over a C8/C10 mix. )  I use 4 to 6 tablespoons of C8 spread out during the day, and have never had side effects.

 

Link to the full text:

 

https://www.research...tive_impairment

 

Many thanks for the link, Heisok. 







Also tagged with one or more of these keywords: acetoacetate, alzheimers disease, beta-hydroxybutyrate, decanoic acid, fluorodeoxyglucose, glucose, ketone, medium chain triglyceride, mild cognitive impairment, octanoic acid

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