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Fisetin accelerates the rate of telomere shortening

fisetin telomere ampk

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#1 Yamu Xu

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Posted 07 May 2019 - 09:52 AM


I read a paper that said Fisetin accelerates the rate of telomere shortening:
 
 
Accelerated Aging during Chronic Oxidative Stress: A Role for PARP-1

 

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AMPK activators can inhibit SASP, and AMPK and mTOR regulate autophagy too, what's more, activate AMPK can protect telomere!

So don't eat fisetin everyday, just eat some safe AMPK activators to control chronic inflammatory.

 

BTW, Alive by Nature's pills of activator contain fisetin, be careful of this.

 

What's more, H2O2 can increase NF-κb and NF-κb can cause chronic inflammatory too, so drinking H2O2 to activate AMPK is not a good idea,  we can eat some safe AMPK activators! I recommend baicalein as AMPK activator, baicalein has a strong effect of anti-cancer, and it can extended life span in  animal experiment, related paper:

 

http://xueshu.baidu....&site=xueshu_se

 

 

 


Edited by Yamu Xu, 07 May 2019 - 09:53 AM.


#2 Yamu Xu

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Posted 07 May 2019 - 10:59 AM

extended life span→extend life span
 
Sorry for some spelling mistakes, English is not my first language.


#3 WillNitschke

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Posted 21 June 2019 - 12:13 PM

"However, under conditions of chronic oxidative stress, both fisetin and minocycline appeared to reduce the rate of telomere shortening. Since our study was limited to testing the effects of fisetin and minocycline in an in vitro model with HF cells that were chronically exposed to oxidative stress more research is needed to evaluate possible positive effects of fisetin and minocycline in chronic inflammatory diseases.

It can be concluded that chronic administration of pharmaceuticals or nutraceuticals with PARP inhibiting activity appears to be beneficial in conditions of chronic oxidative stress, but may be detrimental under relatively normal conditions."

 

This might hint at the possibility that fisetin may be beneficial for older people but counter productive for young healthy people. That might also explain why aged rats benefited so much. But this is all speculation, of course.



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#4 GABAergic

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Posted 21 June 2019 - 10:58 PM

"However, under conditions of chronic oxidative stress, both fisetin and minocycline appeared to reduce the rate of telomere shortening. Since our study was limited to testing the effects of fisetin and minocycline in an in vitro model with HF cells that were chronically exposed to oxidative stress more research is needed to evaluate possible positive effects of fisetin and minocycline in chronic inflammatory diseases.

It can be concluded that chronic administration of pharmaceuticals or nutraceuticals with PARP inhibiting activity appears to be beneficial in conditions of chronic oxidative stress, but may be detrimental under relatively normal conditions."

 

This might hint at the possibility that fisetin may be beneficial for older people but counter productive for young healthy people. That might also explain why aged rats benefited so much. But this is all speculation, of course.

 

good point. i wonder if not just fisetin but many other considered "anti-aging" compounds work the same way. i would definitely not suggest young healthy people to take them, thats for sure. im glad i never fell into the trap of doing fisetin too. all the supplements containing it are generally of poor control and quality so likely i wouldnt even get any real fisetin in me, but still staying on the safe side not using any at all is the best idea.



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#5 WillNitschke

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Posted 21 June 2019 - 11:35 PM

The current trend in longevity research is to find compounds that 'stress' the body, i.e., do damage to it. So this therefore activates and stimulates self repair mechanisms to do more clean-up work. So there is going to be a combination of harm + benefit. You just want the benefit to outweigh the harm. Imagine if researchers looked a muscle fibers after a heavy resistance training session and saw all the cellular damage. The right conclusion to reach would not be to recommend nobody lift heavy weights. So everything depends on context. Unfortunately this field is very complex so it's difficult to make sweeping statements about taking or avoiding such molecules.


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