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Extension of Maximal Lifespan by Transplantation of Bone Marrow

bone marrow transpantation stem cells max life span chimerism

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#1 albedo

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Posted 08 May 2019 - 02:43 PM


Another progress in therapeutics and rejuvenation by stem cells transplantation:

 

Kovina MV, Karnaukhov AV, Krasheninnikov ME, et al. Extension of Maximal Lifespan and High Bone Marrow Chimerism After Nonmyeloablative Syngeneic Transplantation of Bone Marrow From Young to Old Mice. Front Genet. 2019;10:310.

 

Attached File  Bone Marrow Transplantation and Max Life Span.PNG   54.97KB   0 downloads

 

"Conclusions

1. For the first time rejuvenation therapy was started so late, at the point when half of the animals had already died, and the high (31 ± 5%) extension in maximal lifespan of the remaining animals was found. such significant effect on the maximal lifespan, unlike the median lifespan fluctuations, indicates that BM transplantation affects the intrinsic aging mechanism. The life-extending effect was significantly stronger than in earlier works with similar design (no irradiation or chemotherapy, no hereditary pathologies in recipients, advanced age at the start of the BM administration) because of (i) the larger amount of transplanted material and (ii) the close relation of the donors and recipients. The result is encouraging for clinical adaptation for aged humans (70–80-years old).

2. The observed lifespan extension was accompanied by extension of an active and healthy life period.

3. The bone marrow chimerism of recipients after BM transplantation was significant (28% of nucleated BM cells were of donor origin) and permanent (it lasted for at least 6 months after the transplantation), indicating that rejuvenation is caused not only by the paracrine effect but also by direct cell replacement."


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#2 albedo

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Posted 12 May 2019 - 04:38 AM

Commented also here:

https://www.fightagi...-span/#comments


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Also tagged with one or more of these keywords: bone marrow transpantation, stem cells, max life span, chimerism

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