• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Offsetting decline in AMPAr's of ampakines/positive allosteric modulators with AMPA antagonists

ampa racetam ampa antagonism ampa receptors

  • Please log in to reply
No replies to this topic

#1 neural tweaking

  • Guest
  • 6 posts
  • 2
  • Location:New York

Posted 31 May 2019 - 12:07 AM


https://www.ncbi.nlm...les/PMC2746455/

 

Ampakines appear to down regulate AMPA-r density with longer term usage, although the response doesn't occur when the half-life of the ampakine is very short. I'm highly sensitive to acute effects from piracetam (pretty uncommon it seems) and have noticed that when I stop using it, my working memory and attention span suffer a significant deficit comparable to sleep deprivation. Immediately supplementing with piracetam offsets this deficit. Piracetam's long-ish half-life combined with chronic usage seems like a recipe for downregulation of AMPA-r's and decreased LTP when cycling off, which might explain the deficits I've noticed. Has anyone experimented with/tried using AMPA antagonists (maybe l theanine or something stronger) to balance the effect of racetams on AMPA-r's? Has it worked? Is what I'm experiencing totally unrelated to AMPA-r's?







Also tagged with one or more of these keywords: ampa, racetam, ampa antagonism, ampa receptors

2 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users


    Bing (2)