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Quitting Antipsychotics after 6 years

antipsychotics bipolar tapering seroquel dopamine serotonin gaba memory

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#1 BioInfinite

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Posted 30 June 2019 - 03:23 AM

Hi everyone.


I've been on Seroquel for my bipolar II for 6 years and it's been a miserable time. I've tried to come off so many times. Sometimes cold turkey, sometimes tapering but I get so much neural excitation I have to go back to it every time. The problem I think is my dopamine is so upregulated due to antagonism that it overloads when I reduce the dose and I get super stressed and agitated. Also have a poor working/short term memory, sometimes poor cognition. 


Any nootropics etc you think could help. Bear in mind I also have GABA kindling so have to avoid all GABAergics, previous serotonin syndrome so avoid most things that increase serotonin by much. I also think anything cholinergic I'm reacting to as well - can't eat eggs, tried lion's mane and phospholipids with bad reaction.


I've tried Risperidone, its worse than Seroquel. Can't try some other antipsychotics like Aripiprazole due to SERT inhibition or Olanzapine due to GABA activation. Also tried Lamictal but it was too serotonergic. It seems nearly every other mood stabilizer is either GABAergic or serotonergic. Would be open to trying another if it would help. I think I have damage to my serotonin/dopamine/GABA/choline systems but what I can find looks like it also increases their levels which I'm not sure will help. Not really sure how to proceed.


I'm thinking something anti - NMDA / AMPA /glutamate related might help but haven't managed to find anything yet, apart from Dexanabinol which I can't find any reports of.


I'm open to suggestions! Thanks

#2 MichaelFocus22

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Posted 01 July 2019 - 01:43 AM

1. Meditation, Running, Working out and channel that inner bi-polar into a constructive manner. An old friend is in the Bay Area and he seems to get more ladies that I do as an Incel Beta-male. 

  • Pointless, Timewasting x 2
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#3 2 Duckets

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Posted 01 July 2019 - 11:50 PM

Theres an herb called Uncaria Rhynchophylla. It's a Chinese herb used in TCM. Its also the main ingredient in Yokukansan.

It inhibits serotonin activity at the 5-HT2a, 5-HT2c, and 5-HT7 serotonin receptors.
But at the 5-HTA1 serotonin receptor it increases activity.

Also, I think its an agonist to a few melatonin receptors which makes it very relaxing.

I use it to put me in a good relaxed mood and to down regulate my 5-ht2a receptors.

Oh yeah, it's also non GABAergic.

Edited by 2 Duckets, 02 July 2019 - 12:04 AM.

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#4 Automail

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Posted 05 July 2019 - 04:42 PM

Memantine is a NMDA antagonist. I'm not aware of any AMPA inhibitors though.

Also tagged with one or more of these keywords: antipsychotics, bipolar, tapering, seroquel, dopamine, serotonin, gaba, memory

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