• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
* * * * * 1 votes

TRIIM Study

rejuvenation thymus dhea metformin hgh

  • Please log in to reply
5 replies to this topic

#1 lukas_93

  • Guest
  • 4 posts
  • 4
  • Location:Deutschland

Posted 13 July 2019 - 05:04 PM


Did anyone hear about the TRIIM Study by Greg Fahy, I just read about it here: 

 

https://www.zeit.de/...ie-gregory-fahy (german)

 

This is the only english article i found 

https://www.tellerre...Bkgc43H8bB.html

 

I can't find anything related to the presentation online though. 

 

According to the article they used: 
- DHEA 
- Metformin 

- HGH 

to modulate thymus activity

 

 

Does anybody know more? 


  • Informative x 2

#2 sthira

  • Guest
  • 1,972 posts
  • 397

Posted 18 July 2019 - 02:02 AM

Thymus regeneration? You’ll correct me if I’m wrong, or someone will, but I don’t think Dr. Fahy’s results panned so well as anticipated. Am I misinformed? Tell me. Because I’m not totally clear what’s going on with their thymus regeneration efforts since to my knowledge they’ve not released data from their very small scale trials.

I’d love to learn more. And others are working to restore the thymus — all of this is good news, imho.

Meanwhile, From Fahy's patent:

https://www.google.c...tents/US6297212

“The regimen for administering human growth hormone and DHEA or their equivalents for the rejuvenation of the thymus is as described above in the preferred embodiment.

“The regimen should be continued preferably for 1-3 months.

“For best results, this regimen can be supplemented with other immune-system strengthening agents, particularly coenzyme Q10 (10-200 mg/day), Vitamin E (200-1000 IU/day) and zinc (30-100 mg/day). Further, chromium picolinate (100-1000 micrograms/day) may be used to supplement DHEA/DHEA-sulfate.

“First, insulin sensitizing (and therefore lowering) agents other than DHEA and its above-described relatives can be employed in place of DHEA. Chromium picolinate and similar formulae involving chromium (such as “GTF” or glucose tolerance factor preparations available in health food stores) and phenformin represent the only known members of this class of agents. As in the case of DHEA, the appropriate dose is to be adjusted based on the insulin-lowering response attained in a particular patient. Chromium picolinate is particularly exciting because of its low toxicity, its ability to extend the life span of animals by 50%

“Consequently, a third choice for thymic regeneration is to use 30-130 mg/day of zinc plus 200-1000 IU/day of Vitamin E plus 10-200 mg/day of coenzyme Q10 for 1-3 months. This approach will be desirable when HGH and DHEA or their equivalents cannot be used for any reason.

“...a surgeon skilled at thymic biopsy retrieval injects into the thymus an appropriate sample of the tissue or organ to be transplanted later, or injects any other donor-specific cells or antigens (for example, bone marrow cells) that are the immunological equivalent of the tissue itself in stimulating deletion or anergy of the cells otherwise responsible for later rejecting the transplanted tissue or organ.”

While we wait, I’m not advising this, but here’s one possible (but probably ineffective) strategy to regrow that thing:

1: Baseline—begin 15 gm/day administration of arginine;

2: Day 7—begin 180 mg/day DHEA;

3: Day 14—begin 15 gm arginine every other day or 7.5 g/day; and

4: Day 21—end of experiment, no arginine administered the previous night.

--DHEA equivalent dose of 50-2000 mg, more preferably 50-1000 mg/day...

I need references, don’t I, and seem to have lost them. Keep digging, folks, the health and regrowth of your thymus is super important.
  • Informative x 2

To book this BIOSCIENCE ad spot and support Longecity (this will replace the google ad above) - click HERE.

#3 Harkijn

  • Member
  • 642 posts
  • 182
  • Location:Amsterdam
  • NO

Posted 08 August 2019 - 02:07 PM

For more background to this also read this older thread:

https://www.longecit...s-rejuvenation/


Edited by Michael, 08 September 2019 - 01:48 AM.
Removing Google tracking materials (no malfeasance on poster's part).

  • like x 1

#4 8bitmore

  • Guest
  • 337 posts
  • 108

Posted 06 September 2019 - 06:52 PM

Cheers to lukas_93 for getting here early, an update was released on the outcomes from this study yesterday (https://www.nature.c...586-019-02638-w). Would love to see actual basic research paper but have had no luck getting access to it so have no idea about specific dosages..etc. as of yet.

 

Here's excerpts of interest from the article:

 

"In a small trial, drugs seemed to rejuvenate the body’s ‘epigenetic clock’, which tracks a person’s biological age

...

For one year, nine healthy volunteers took a cocktail of three common drugs — growth hormone and two diabetes medications — and on average shed 2.5 years of their biological ages, measured by analysing marks on a person’s genomes. The participants’ immune systems also showed signs of rejuvenation

...

The Thymus Regeneration, Immunorestoration and Insulin Mitigation (TRIIM) trial tested 9 white men between 51 and 65 years of age. It was led by immunologist Gregory Fahy, the chief scientific officer and co-founder of Intervene Immune in Los Angeles, and was approved by the US Food and Drug Administration in May 2015. It began a few months later at Stanford Medical Center in Palo Alto, California.

....

In the TRIIM trial, the scientists took blood samples from participants during the treatment period. Tests showed that blood-cell count was rejuvenated in each of the participants. The researchers also used magnetic resonance imaging (MRI) to determine the composition of the thymus at the start and end of the study. They found that in seven participants, accumulated fat had been replaced with regenerated thymus tissue.
....
Checking the effect of the drugs on the participants’ epigenetic clocks was an afterthought. The clinical study had finished when Fahy approached Horvath to conduct an analysis.
....
Horvath used four different epigenetic clocks to assess each patient’s biological age, and he found significant reversal for each trial participant in all of the tests. “This told me that the biological effect of the treatment was robust,” he says. What’s more, the effect persisted in the six participants who provided a final blood sample six months after stopping the trial, he says.
....
'Because we could follow the changes within each individual, and because the effect was so very strong in each of them, I am optimistic,' says Horvath."


  • Informative x 1
  • like x 1

#5 Harkijn

  • Member
  • 642 posts
  • 182
  • Location:Amsterdam
  • NO

Posted 07 September 2019 - 03:42 PM

I  place the full study for your scrutiny here. You may also want to check Josh Mitteldorf's take on this on his website Aging Matters. 

 

 

Attached Files


Edited by Harkijn, 07 September 2019 - 03:43 PM.

  • Informative x 3

To book this BIOSCIENCE ad spot and support Longecity (this will replace the google ad above) - click HERE.

#6 GreenPower

  • Guest
  • 199 posts
  • 63
  • Location:Europe

Posted 07 September 2019 - 10:28 PM

After reading the article in Nature I had thoughts on trying this regimen myself.

 

Then I read the study attached above and also the in-depth analysis at Aging Matters.

 

I think the main problems to solve is that:

1. You need a medical prescription to get hold of Metformin, DHEA, and Omnitrope in Europe.

2. At the "Beginning at the fourth week, all doses were individualized based on each volunteer's particular responses". So the doses need to be personalized.

3. You need to take multiple MRI's and two methylation testing procedures in order to verify the results.

 

It will be kind of hard to do this regimen without access to a willing doctor/lab and some serious money, but if anyone out there accepts enrollments from Europeans for a new study, I'm a willing test subject.

 

 


  • Good Point x 1

Click HERE to rent this BIOSCIENCE adspot to support LongeCity (this will replace the google ad above).




Also tagged with one or more of these keywords: rejuvenation, thymus, dhea, metformin, hgh

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users