It gave me diarrhea each time I took it. (Multiple sources, tried a few times). Arjuna does not do this but I don't think it's as useful for me as using Citrulline + Glutathione for circulation.
My Calcium score is zero (probably due to Vitamin C plus Concentrated K intake), but I like the benefits for working out. I cycle it or else my BP drops too much, especially if combined with Agmatine.
More Info:
https://www.ncbi.nlm...pubmed/15311993
Hypotensive effect of agmatine, arginine metabolite, is affected by NO synthase.
Gerová M1, Török J.
Author information
1
Institute of Normal and Pathological Physiology, Slovak Academy of Sciences, Sienkiewiczova 1, 813 71 Bratislava, Slovak Republic. gerova@unpf.savba.sk
Abstract
The metabolites of arginine were recently shown to be involved in cardiovascular control. The study addresses the general cardiovascular response of anaesthetized rats to agmatine, a decarboxylated arginine. The relation between two arginine metabolic pathways governed by arginine decarboxylase and nitric oxide synthase was investigated. Intravenous administration of agmatine 30 and 60 microM/0.1 ml saline elicited remarkable hypotension of 42.6+/-4.6 and 70.9+/-6.5 mm Hg, respectively. The hypotension was characterized by long duration with half-time of return 171.6+/-2.9 and 229.2+/-3.8 s, respectively. The time of total blood pressure BP recovery was about 10 min. Dose-dependent relaxation to agmatine was also found in aorta rings in vitro. Both doses of agmatine administered 60-180 min after NO synthase inhibition L-NAME 40 mg/kg i.v. caused greater hypotension 59.0+/-7.6 and 95.8 8.8 mm Hg P<0.01 both compared to animals with intact NO synthase, but this was accompanied by a significant shortening of the half-time of BP return. If agmatine was administered to hypertensive NO-deficient rats treated with 40 mg/kg/day L-NAME for 4 weeks, similar significant enhancement of hypotension was observed at both agmatine doses, again with a significant shortening of half-time of BP return. It can be summarized that the long-lasting hypotension elicited by agmatine was amplified after acute or chronic NO synthase inhibition, indicating a feedback relation between the two metabolic pathways of arginine.
https://www.ncbi.nlm...les/PMC4472409/
Combined L-citrulline and glutathione supplementation increases the concentration of markers indicative of nitric oxide synthesis
Conclusions
Combining L-citrulline with GSH augments increases in nitrite and NOx levels during in vitro and in vivo conditions.