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Kososan prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated mice

kososan social avoidance depression anxiety csds

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#1 gintrux

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Posted 20 October 2019 - 09:53 AM


I stumbled upon this substance named Kososan which has no mention on reddit or longecity, however has a few clinical studies with interesting results

Kososan, a Kampo medicine, prevents a social avoidance behavior and attenuates neuroinflammation in socially defeated mice: https://www.ncbi.nlm...les/PMC5415730/

CSDS - Chronic Social Defeat Stress

Oral administration of kososan extract alleviated social avoidance, depression- and anxiety-like behaviors, caused by CSDS exposure. CSDS exposure resulted in neuroinflammation, as indicated by the increased accumulation of microglia, the resident immune cells of the brain, and their activation in the hippocampus, which was reversed to normal levels by treatment with kososan extract. Additionally, in ex vivo studies, CSDS exposure potentiated the microglial pro-inflammatory response to a subsequent LPS challenge, an effect that was also blunted by kososan extract treatment. Indeed, the modulatory effect of kososan extract on neuroinflammation appears to be due to a hippocampal increase in an anti-inflammatory phenotype of microglia while sparing an increased pro-inflammatory phenotype of microglia caused by CSDS. Moreover, reduced adult hippocampal neurogenesis in defeated mice was recovered by kososan extract treatment.

Kososan, a standardized traditional Japanese herbal medicine, reverses sleep disturbance in socially isolated mice via GABAA-benzodiazepine receptor complex activation: https://www.ncbi.nlm...pubmed/24300331


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#2 Daniel Cooper

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Posted 29 October 2019 - 02:19 PM

Is Kososan available commercially?

 



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#3 gintrux

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Posted 30 October 2019 - 09:49 AM

Check this thread https://www.reddit.c...e_behavior_and/



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Also tagged with one or more of these keywords: kososan, social avoidance, depression, anxiety, csds

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