From CRsociety mailing list:
Subject: [CR] Too much vitamin D vs aging?
It appears thatone of the
http://en.wikipedia...._growth_factors and
http://en.wikipedia....lotho_(biology) may be required for longer
lives. It now appears that consumption of excessive amounts of vitamin D
may cause a reduction in longevity and calcifications that may be
detrimental for longer living. How much vitamin D is excessive is not
completely clear. The below paper is not pdf-available.
Razzaque MS, Lanske B.
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and
Klotho mutant mice.
Trends Mol Med. 2006 May 25; [Epub ahead of print]
PMID: 16731043 http://tinyurl.com/rhwph
The essential role of low levels of vitamin D during aging is well
documented. ... Recent in vivo genetic-manipulation studies have shown
increased serum level of vitamin D and altered mineral-ion homeostasis in
mice that lack either fibroblast growth factor 23 (Fgf23) or klotho (Kl)
genes. These mice develop identical phenotypes consistent with premature
aging. Elimination or reduction of vitamin-D activity from Fgf23 and Kl
mutant mice, either by dietary restriction or genetic manipulation could
rescue premature aging-like features and ectopic calcifications, resulting
in prolonged survival of both mutants. Such in vivo experimental studies
indicated that excessive vitamin-D activity and altered mineral-ion
homeostasis could accelerate the aging process.