3 replies to this topic

[opales]

From CRsociety mailing list:

Subject: [CR] Too much vitamin D vs aging?

It appears thatone of the
http://en.wikipedia...._growth_factors and
http://en.wikipedia....lotho_(biology) may be required for longer
lives.  It now appears that consumption of excessive amounts of vitamin D
may cause a reduction in longevity and calcifications that may be
detrimental for longer living.  How much vitamin D is excessive is not
completely clear.  The below paper is not pdf-available.

Razzaque MS, Lanske B.
Hypervitaminosis D and premature aging: lessons learned from Fgf23 and
Klotho mutant mice.
Trends Mol Med. 2006 May 25; [Epub ahead of print]
PMID: 16731043  http://tinyurl.com/rhwph
    The essential role of low levels of vitamin D during aging is well
documented. ... Recent in vivo genetic-manipulation studies have shown
increased serum level of vitamin D and altered mineral-ion homeostasis in
mice that lack either fibroblast growth factor 23 (Fgf23) or klotho (Kl)
genes. These mice develop identical phenotypes consistent with premature
aging. Elimination or reduction of vitamin-D activity from Fgf23 and Kl
mutant mice, either by dietary restriction or genetic manipulation could
rescue premature aging-like features and ectopic calcifications, resulting
in prolonged survival of both mutants. Such in vivo experimental studies
indicated that excessive vitamin-D activity and altered mineral-ion
homeostasis could accelerate the aging process.

[scottl]

In recent years it has become clear that the 400 IU of vit D that has been the norm and the old fears of taking too much and vit D toxicity are not realistic (edit: not realistic unless you're taking doses far larger then 1000 IU).

800 or 1000 IU/day is more like the optimal dose.

There are numerous abstracts on this including data on vit d being important in preventing various human cancers.

Edited by scottl, 30 May 2006 - 11:06 PM.

[xanadu]

Good old opales, the devils advocate of the noot world. I think we will all agree that you can take too much D and suffer from it. Keep up the good work.

[ajnast4r]

why do you keep posting anti-vitamin studies with NO AMOUNTS LISTED...its getting rediculous.

general consensus:

winter/no direct sun contact = 1000IU/day
summer/direct sun contact 30 minutes per day = 400IU/day

very safe, and very beneficial.