
#1
Posted 24 November 2019 - 12:09 PM
#2
Posted 24 November 2019 - 02:36 PM
i hope you're aware that a standard-dose (used in the trials) is about 40 mg. also, there's more and more evidence pointing to inflammation causing memory issues. google brain fog + inflammation.
#3
Posted 24 November 2019 - 03:35 PM
i hope you're aware that a standard-dose (used in the trials) is about 40 mg. also, there's more and more evidence pointing to inflammation causing memory issues. google brain fog + inflammation.
Thank you for the advice. I have read through the NSI-189 paper and know that the maximum dose in human trials is 120 mg daily.
The amount of NSI-189 that was administered to rats during the experiment was 30 mg / kg, so when converted to humans, this amount is about 300 mg.
How_to_convert_human_dose_to_animal_dose
https://www.research..._to_animal_dose
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#4
Posted 25 November 2019 - 01:44 PM
#5
Posted 26 November 2019 - 06:50 PM
I don't feel any big change in physical condition or psychological state so far.
I will refrain from taking NSI-189 for a week, as I will have a medical checkup next week. After that, I will resume taking it.
#6
Posted 28 November 2019 - 04:02 AM
#7
Posted 28 November 2019 - 05:48 AM
I decided to stop taking it until next week. This is because next week's examination is related to this unexplained physical condition, and the cause may be overlooked by improving the physical condition due to the effect of NSI-189.
Stop taking NSI-189 for a week.
#8
Posted 05 December 2019 - 10:09 PM
I took 110mg at a time a few hours ago, but for now I don't feel the effect.
#9
Posted 06 December 2019 - 12:17 AM
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#10
Posted 06 December 2019 - 01:32 PM
The total dose of NSI-189 today is 220 mg.
The only change I feel so far is an increase in sleepiness.
#11
Posted 08 December 2019 - 06:41 PM
I feel that the words have come out fluently, but since it may be just a presumption, I will refrain from making a decision about it.
Even considering the use of machine translation, I think it is clear from the composition of my posts that my original linguistic skills are low.
Frequent progress reports help to observe this change in sentence composition objectively.
#12
Posted 08 December 2019 - 08:12 PM
I took 110 mg x 2 NSI-189 yesterday, but the only effects I feel so far are sleepiness and a real nightmare.
I feel that the words have come out fluently, but since it may be just a presumption, I will refrain from making a decision about it.
Even considering the use of machine translation, I think it is clear from the composition of my posts that my original linguistic skills are low.
Frequent progress reports help to observe this change in sentence composition objectively.
I had a lot of sleepiness early in my treatment with NSI. I recommend you keep going with it as the sleepiness faded away for me and then the real benefits were more discernible.
#13
Posted Yesterday, 03:51 PM
I had a lot of sleepiness early in my treatment with NSI. I recommend you keep going with it as the sleepiness faded away for me and then the real benefits were more discernible.
Thank you for the advice. I would like to continue taking NSI-189.
Edited by mikunimaru, Yesterday, 03:53 PM.
#14
Posted Yesterday, 03:54 PM
And I was able to indulge in thinking even when I was not doing anything, it's still hard to say whether this is the effect of NSI-189 or the effect of getting enough sleep.
I also have back pain, which I think is not a side effect of NSI-189, but simply because of my bad sleeping posture.
#15
Posted Today, 01:16 AM
DO NOT TAKE excessive doses of NSI-189. I am probably the only person who has dosed in the range you are planning on, and it was hell. A single ~400 mg dose completely killed my passion and joy for life for a year, and it has taken another year to approach a full recovery. I have previously had great results taking ~ 100 mg (50 mg x 2 /day), so I thought 400 mg should still be relatively safe. I was wrong.
Max I would suggest is 50 mg x 3 / day. Any more than that is unlikely to be of additional benefit.
Neurogenesis is dependent on a hormetic mechanism involving free radical signalling, much like the muscle and endurance one gains from exercise (for example, vitamin C megadoses improve initial performance but impair cardiovascular gains from endurance training). My guess is that too much NSI-189 overloads the brain with oxidative stress which becomes detrimental rather than beneficial.
#16
Posted Today, 02:16 AM
DO NOT TAKE excessive doses of NSI-189. I am probably the only person who has dosed in the range you are planning on, and it was hell. A single ~400 mg dose completely killed my passion and joy for life for a year, and it has taken another year to approach a full recovery. I have previously had great results taking ~ 100 mg (50 mg x 2 /day), so I thought 400 mg should still be relatively safe. I was wrong.
Max I would suggest is 50 mg x 3 / day. Any more than that is unlikely to be of additional benefit.
Neurogenesis is dependent on a hormetic mechanism involving free radical signalling, much like the muscle and endurance one gains from exercise (for example, vitamin C megadoses improve initial performance but impair cardiovascular gains from endurance training). My guess is that too much NSI-189 overloads the brain with oxidative stress which becomes detrimental rather than beneficial.
Please tell me more. After hearing your opinion, I would like to decide whether to continue taking the current dose.
What is hell? What does it mean that joy is lost?
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