• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
- - - - -

Drugs that quell brain inflammation reverse dementia

dementia brain

  • Please log in to reply
5 replies to this topic

#1 elfanjo

  • Guest
  • 68 posts
  • 2
  • Location:Canada

Posted 09 December 2019 - 12:35 PM


https://news.berkele...verse-dementia/

Interesting article, but they don't mention which drug(s) they used...

I wonder if someone in longecity knows ?

Edited by elfanjo, 09 December 2019 - 12:36 PM.


#2 Daniel Cooper

  • Member, Moderator
  • 1,613 posts
  • 245
  • Location:USA

Posted 16 December 2019 - 02:55 PM

I don't know what drugs they used but presumably you could look on PubMed for those researchers names and it should be one of their more recent papers.  I'll do that but it will be this evening at earliest.

 

 


Edited by Daniel Cooper, 16 December 2019 - 02:56 PM.


sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#3 Turnbuckle

  • Member
  • 3,990 posts
  • 1,697
  • Location:USA
  • NO

Posted 16 December 2019 - 03:56 PM

Angiotensin receptor blockers like Losartan are used for hypertension, and also reduce brain inflammation and improve AD symptoms in lab animals.

 

Angiotensin IV Receptors Mediate the Cognitive and Cerebrovascular Benefits of Losartan in a Mouse Model of Alzheimer's Disease.


  • Informative x 1

#4 elfanjo

  • Topic Starter
  • Guest
  • 68 posts
  • 2
  • Location:Canada

Posted 17 December 2019 - 08:00 PM

I found that :
https://www.ncbi.nlm...iela Kaufer#fft

The full paper is behind a paywall...
They talk about therapeutic inhibition of TGFβ signaling.

I'll look into this and post my findings here.

Edited by elfanjo, 17 December 2019 - 08:00 PM.


#5 Turnbuckle

  • Member
  • 3,990 posts
  • 1,697
  • Location:USA
  • NO

Posted 18 December 2019 - 01:56 AM

I found that :
https://www.ncbi.nlm...iela Kaufer#fft

The full paper is behind a paywall...
They talk about therapeutic inhibition of TGFβ signaling.

I'll look into this and post my findings here.

 

It appears from the full paper that the drug is IPW-5371. See this preprint: https://www.biorxiv....537431.full.pdf

 

It's a TGFβR inhibitor, and natural inhibitors are known--

 

We investigated whether EGCG and myricetin could decrease the TGFβR1 expression in HepG2 and PC3 cells. After 48 h of treatment with EGCG and myricetin, determine the mRNA expression of TGFβR1 by using RT-PCR. As shown in Figure 4, RTPCR demonstrates that EGCG have a prospective for forceful inhibition of TGFβR1. The RT-PCR densitometric bands examination showed that EGCG reduced the mRNA expression of TGFβR1 by 15% in HepG2 (*P<0.05) and 70% (**p<0.001) in PC3 cells at 80 μM concentration. Whereas, RTPCR densitometric bands investigation showed that myricetin reduced the mRNA expression of TGFβR1 by 20% in HepG2 (*P<0.05) and 80% (**p<0.001) in PC3 cells at 80 μM concentrations. 

 

 

Myricetin greatly increased the number of hippocampal CA3 pyramidal neurons and improved learning and memory impairments in rats with Alzheimer's disease. These findings suggest that myricetin is beneficial for treatment of Alzheimer's disease.

https://www.ncbi.nlm...pubmed/28197195

 

 

I'd previously included Dihydromyricetin in my AD protocol.


Edited by Turnbuckle, 18 December 2019 - 02:14 AM.


sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#6 elfanjo

  • Topic Starter
  • Guest
  • 68 posts
  • 2
  • Location:Canada

Posted 23 December 2019 - 01:14 PM

Thxs I will look into this





Also tagged with one or more of these keywords: dementia, brain

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users