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The importance of nicotinamide adenine dinucleotide phosphate (NADPH) homeostasis in the survival of cancer cells

nadph cancer ppp

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#1 osris

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Posted 03 January 2020 - 04:42 PM


Is this saying that NADPH keeps cancer cells active?
 
"Cancer cells adapt their metabolic circuitry to support proliferation under nourished fast-life as well as to survive under starved slow-life. Emerging evidence suggests that PPP flux is increased in human cancer and that the PPP plays an important role in cancer progression although the oncogenic regulation of PPP is not fully understood yet. During the natural history of cancer initiation and progression, cancer cells are inevitably and repeatedly exposed to a metabolic starved environment. Under starved condition, the ATP and NADPH are essential to the slow-life of cancer cells. The ATP is generated by the oxidation (mainly from oxidative phosphorylation in mitochondria) of many molecules such as glucose, fatty acids, and amino acids. NADPH mainly generated from PPP is the major electron donor in reductive biosynthesis supporting the oxidation process. As discussed earlier, cancer cells have acquired mechanisms to activate PPP based on metabolic demand. Further studies will uncover additional mechanisms by which cancer cells utilize the PPP to support their survival and proliferation. Also, more work is needed to find a novel and specific therapeutics for hyperactive PPP in human cancer."
 
 






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