5 replies to this topic

[ihatesnow]

https://www.this-is-...1qYM5cviHhhSbkA

[kurdishfella]

i rather die early then live long and look like that

[Dorian Grey]

(from the link) "Oldest Italian Grandmother said she Reached 116-years by Eating Chocolate every Day"

 

Jeanne Calment, the world's longest lived human (122) ate a kilo of chocolate per week too.  

 

https://en.wikipedia.../Jeanne_Calment

 

"She enjoyed chocolate, sometimes indulging in a kilogram (2.2 lb) per week"

 

Theobromine (a xanthine) in chocolate inhibits xanthine oxidaise activity. 

 

XO is known to liberate iron (the ultimate pro-oxidant) from ferritin.  https://www.ncbi.nlm...les/PMC1147813/

 

Ferrotoxic Disease & the Iron Hypothesis of aging and disease validated once again. 

 

https://www.longecit...isease-omnibus/

 

Keep ferritin out of triple digits, or at least under control with xanthines or natures chelators (curcumin, quercetin & IP6/phytic acid) and you may set a record of your own!  

Edited by Dorian Grey, 09 January 2020 - 04:39 AM.

[OlderThanThou2]

(−)-Epicatechin induced reversal of endothelial cell aging and improved vascular function: underlying mechanisms

 

 

The consumption of cocoa products rich in (−)-epicatechin is associated with reduced cardiovascular risk and improved vascular function. However, little is known about (−)-epicatechin’s effects on aged endothelium. In order to characterize the health restoring effects of (−)-epicatechin on aged endothelium and identify the underlying mechanisms, we utilized high passage number (i.e. aged) bovine coronary artery endothelial cells and aortas of 3 and 18 month old rats. We evaluated cell senescence (β-galactosidase), nitric oxide (NO) production through the endothelial nitric oxide synthase pathway, mitochondria related endpoints, citrate synthase activity and vascular relaxation. Cells were treated with water or (−)-epicate-chin (1 μM) for 48 h and rats orally with either water or (−)-epicatechin (1 mg kg−1 day−1) for 15 days. Senescence associated β-galactosidase levels doubled in aged cells while those treated with (−)-epicate-chin only evidenced an ~40% increase. NO levels in cells decreased by ~33% with aging and (−)-epicate-chin normalized them. Endothelial nitric oxide synthase phosphorylation levels paralleled these results. Aging increased total protein and synthase acetylation levels and (−)-epicatechin partially restored them to those of young cells by stimulating sirtuin-1 binding to the synthase. Phosphorylated sirtuin-1, mitofilin, oxidative phosphorylation complexes and transcriptional factor for mitochondria were reduced by ~40% with aging and were restored by (−)-epicatechin. (−)-Epicatechin enhanced acetylcholine induced aged aorta vasodilation and stimulated NO levels while reducing blood pressure. In conclusion, (−)-epicatechin reverses endothelial cell aging and restores key control elements of vascular function. These actions may partly explain the epidemiological evidence for the beneficial effects of cocoa consumption on the incidence of cardiac and vascular diseases.

 

[adamh]

There is controversy over jeanne calment and her true age. Many years ago jeanne's daughter died (officially) but there is a theory that the mother died and the daughter assumed her identity. Jeanne had an inheritance coming but it would not pass through if she died before the benefactor. She also had a pension which would extinguish upon her death. The family was having financial difficulties at the time. So by taking her mother's place all that would be preserved

 

https://www.newscien...ase-of-calment/

[OlderThanThou2]

People who used to know her are kind of unnerved by the fact that her age has been put in doubt. I don't know for sure personally.