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theaflavins are senolytic?

senolytic

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#1 sedentary

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Posted 15 January 2020 - 05:23 PM


i didnt know this about theaflavins but then i read this article; https://www.lifeexte...senescent-cells

so whats the deal with theaflavins. i know lifeextension usually exaggerates so they sell more products but the article does have good points. do you think theaflavins can fall into the senolytic category??



#2 kench

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Posted 11 February 2020 - 11:53 PM

I am using the LEF senolytic product, but I don't have much to report on as of now.


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#3 Iporuru

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Posted 12 February 2020 - 06:13 AM

Reducing Hypothalamic Stem Cell Senescence Protects against Aging-Associated Physiological Decline

 

Highlights

  • The lncRNA Hnscr is highly expressed in htNSCs of young mice but decreases during aging
  • Hnscr depletion promotes the senescence of htNSCs and aging-like phenotypes
  • Hnscr attenuates htNSC senescence by binding to YB-1 to prevent its degradation
  • Theaflavin 3-gallate mimics Hnscr and ameliorates aging-related physiological disorders

Summary

Age-dependent loss of hypothalamic neural stem cells (htNSCs) is important for the pathological consequences of aging; however, it is unclear what drives the senescence of htNSCs. Here, we report that a long non-coding RNA, Hnscr, is abundantly expressed in the htNSCs of young mice but decreases markedly in middle-aged mice. We show that depletion of Hnscr is sufficient to drive the senescence of htNSCs and aging-like phenotypes in mice. Mechanistically, Hnscr binds to Y-box protein 1 (YB-1) to prevent its degradation and thus the attenuation of transcription of the senescence marker gene p16 INK4A. Through molecular docking, we discovered that a naturally occurring small compound, theaflavin 3-gallate, can mimic the activity of Hnscr. Treatment of middle-aged mice with theaflavin 3-gallate reduced the senescence of htNSCs while improving aging-associated pathology. These results point to a mediator of the aging process and one that can be pharmacologically targeted to improve aging-related outcomes.

 


Edited by Iporuru, 12 February 2020 - 06:14 AM.

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#4 johnross47

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Posted 20 February 2020 - 07:57 PM

I treat myself with this stuff every day; usually about a litre of tea.


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#5 sedentary

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Posted 21 February 2020 - 01:29 AM

a liter of water might be fine, but tea... i even know some people having that much coffee too. not sure its good for you long term



#6 johnross47

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Posted 09 March 2020 - 10:22 PM

I've been drinking tea since I was a child, like many people in the UK and I'm 73 now. I've never seen anything that made it look at all dangerous or harmful.



#7 sedentary

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Posted 10 March 2020 - 11:39 PM

oh wow so you probably consumed a lot of theaflavins in your life. i mean, what, like 60 years regularly perhaps? tea also contains quercetin. so i guess you should be experiencing senescence. can you feel it or see it somehow? probably take a test, like one of those telemores DNA tests



#8 johnross47

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Posted 19 March 2020 - 07:23 PM

I probably was introduced to tea by the time I was about 7 or 8, but being Scottish, it was drunk with quite a bit of milk, which would soak up the oxalic acid component. I take a lot less milk now, but still some.



#9 aribadabar

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Posted 20 March 2020 - 08:18 PM

Correct, adding milk to tea negates its beneficial properties.



#10 johnross47

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Posted 20 March 2020 - 09:32 PM

Interesting...I usually drink green tea neat as they say, and black tea with a small amount of milk ....I must measure how much. I could probably learn to drink it black, but then of course there would be the oxalic acid issue.??????



#11 sedentary

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Posted 22 March 2020 - 05:20 PM

Correct, adding milk to tea negates its beneficial properties.

 

any chance on figuring out which type of black teas contain what amount of theaflavins?



#12 johnross47

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Posted 23 March 2020 - 07:15 PM

http://seanol.com.br...e/artigos/8.pdf







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