LONGECITY

I'm excited about what I've seen on Hesperidin regarding blocking the COVID virus at the ACE2 sites it must enter in order to start replicating. 

https://www.scienced...211383520302999

"However, most of above compounds were not predicted to bind with the binding interface of the Spike–ACE2 complex. The only compound that could target the binding interface between Spike and ACE2 was hesperidin"

Hesperidin is available as a supplement, but orange juice is a natural source.  Interestingly, fresh frozen concentrate seems to have the highest hesperidin levels.  The hesperidin is in the rind, and the commercial orange crushers used to make commercial juice squeeze the fruit so hard that more hesperidin is released.  Hesperidin will precipitate out of bottled orange juice (that white stuff that forms in the bottom of the bottle) but frozen OJ apparently provides the best dose of hesperidin.  

So does anyone think that this treatment could actually be true?

Purine Repressing Probiotic Might Halt COVID-19, says Korean Researchers

https://geneonline.n...an-researchers/

Heat-killed L. gasseri enhanced immunity in the elderly. This probiotic increases the number of CD8(+) T cells and

reduces CD28 expression loss in CD8(+) T cells.

https://www.ncbi.nlm...pubmed/25653155

Heat-killed L. gasseri increased natural killer cell (NK cell) activities and enhanced cell-mediated immunity in aged

host animals, thereby altering age-related immunosenescence

https://www.ncbi.nlm...pubmed/22092995

Live and heat-killed L. gasseri protected mice against the influenza virus and ameliorated infection symptoms, apparently

by stimulating local and systemic immune responses.

https://www.ncbi.nlm...les/PMC3982165/

https://www.ncbi.nlm...pubmed/22098223

L. gasseri exhibited anti-herpes virus (HSV-2) activity.

https://www.ncbi.nlm...pubmed/25752765

News Flash: Mike Pence is saying the FDA has approved hydroxychloloquine for off label use.  

New York Gov. Andrew Cuomo announced that the state has acquired 70,000 doses of hydroxychloroquine, 10,000 doses of the antibiotic zithromax and 750,000 doses of chloroquine, with trials set to start Tuesday.

Looks like they are going to allow chloroquine too and not just hydroxychloroquine.  Have seen reports hydroxychloroquine is now is short supply with lupus patients saying their pharmacy is back-ordered.   Looks like there is lots of chloroquine lying around though.  

Godspeed New York!  

It looks like Taurine might increase ACE2 expression. I'm unclear if this is good or bad.

Adv Exp Med Biol. 2017;975 Pt 2:871-886.

New York hospitals are treating all coronavirus patients with high doses of IV VITAMIN C after promising results from China

https://www.dailymai...-VITAMIN-C.html

Dr Andrew Weber shared that he has been immediately giving his intensive-care patients 1,500 milligrams of intravenous vitamin C

The Long Island based pulmonologist and critical-care specialist with Northwell Health shared that patients are given three to four doses a day

Jason Molinet, a spokesman for Northwell, said that Vitamin C is being 'widely used' as a coronavirus treatment throughout the health system

FDA approves first US coronavirus treatment: Doctors across the US can now treat the sickest Americans with plasma from recovered patients

https://www.dailymai...-newly-ill.html

Plasma transfusion has been used in China to treat COVID-19 patients, but is limited by the number of recovered people to donate

---------------------------

Wonder how much this plasma might be worth?  Blood donor for hire!  Or perhaps they will just import it from China like everything else.  

Maybe Emodin was posted already. Below are old studies. A recent article on COVID-19, talks about using Toremifene plus Emodin and says: "Emodin, an anthraquinone derivative extracted from the roots of rheum tanguticum, has been reported to have various anti-virus effects. Specifically, emdoin inhibited SARS-CoV-associated 3a protein70, and blocked an interaction between the SARS-CoV spike protein and ACE2 (ref. 71). Altogether, network analyses and published experimental data suggested that combining toremifene and emdoin offered a potential therapeutic approach for 2019-nCoV/SARS-CoV-2 (Fig. 6c)."

Antiviral Res. 2007 May;74(2):92-101. Epub 2006 May 15.

So they still believe that the increase in ACE2 expression puts individuals at higher risk of infection.

https://www.thelance...0116-8/fulltext

So do you increase ACE2 expression or not?

I've been trying to figure out the ACE2 enzyme connection myself.  The virus is supposed to enter cells to replicate through the ACE2 receptor.  

What I don't know is whether or not the ACE2 enzyme carries or guides the virus to the ACE2 receptor sites or not.  I'm kind of thinking this might be might be the case.  The virus doesn't have eyes, and the thought it might simply float around until it randomly bumped into a receptor sounds unlikely.  Something guides it to the receptor.  The ACE2 enzyme is a likely suspect.  

My Spidey sense is tingling...  Did a real doctor just mention zinc? 

https://www.mediamat...-regimen-doctor

Sean Hannity reads Mike Pence a letter from unidentified doctor detailing a drug “regimen” the doctor claims prevents coronavirus deaths

"This (New York doctor) and his team have now treated approximately 350 patients in Kiryas Joel, it was an area of New York that was hit particularly hard and another 150 patients and other New York areas. 

"Hydroxychloroquine, 200 milligrams twice a day, five days. Azithromycin, 500 milligrams once a day, five days. Zinc sulfate, 220 milligrams once a day for five days"

"His results, we have had zero deaths, zero hospitalizations, zero intubations, zero."

Got Zinc?

US doctors are prescribing THEMSELVES experimental drugs Trump touted for treating coronavirus and hoarding the pills

https://www.dailymai...oronavirus.html

US doctors are prescribing themselves hydroxychloroquine in large quantities, a ProPublica report found

US doctors are hoarding supplies of drugs that are being tested for treating coronavirus.  Pharmacists in Miami and Houston have had similarly suspicious prescriptions called in by doctors making large orders of the drugs to stockpile and lupus patients throughout the US have complained they can't get their medication.

How do I buy stock in these companies?  

I've been trying to figure out the ACE2 enzyme connection myself.  The virus is supposed to enter cells to replicate through the ACE2 receptor.  

 

What I don't know is whether or not the ACE2 enzyme carries or guides the virus to the ACE2 receptor sites or not.  I'm kind of thinking this might be might be the case.  The virus doesn't have eyes, and the thought it might simply float around until it randomly bumped into a receptor sounds unlikely.  Something guides it to the receptor.  The ACE2 enzyme is a likely suspect.  

Here is what some immunologists think about how the ACE2 is impacted by this virus:

"SARS-CoV and SARS-CoV-2 both use the same keyhole to enter cells, the ACE2 receptor. There’s an abundance of this receptor in cells in the lower lung which may explain the high incidence of pneumonia and bronchitis in those with severe COVID-19 infection.

A recent study showed that ACE2 is also highly expressed in the mouth and tongue, granting the virus easy access to a new host. ACE2 receptor abundance goes down in the elderly in all these tissues, but, counter intuitively, this might place them at a greater risk of severe illness.

This is because the ACE2 enzyme is an important regulator of the immune response, especially inflammation. It protects mice against acute lung injury triggered by sepsis. A 2014 study found that the ACE2 enzyme offers protection against lethal avian influenza. Some patients with better outcomes had higher levels of the protein in their sera, and turning off the gene for ACE2 led to severe lung damage in mice infected with H5N1, while treating mice with human ACE2 dampened lung injury. 

A fall in ACE2 activity in the elderly is partly to blame for humans’ poorer ability to put the brakes on our inflammatory response as we age, according to comments from Honpeng Jia of Johns Hopkins Medicine. Reduced abundance of ACE2 receptors in older adults could leave them less able to cope with SARS-CoV-2"

So if these immunologists are correct then they are saying that in the elderly there is reduced amounts of ACE2 and that is why they are suffering the worst damage to their lungs....and younger people have higher ACE2 and that is why it is not hitting them as hard.

Based upon this information I would take it that you would want to increase ACE2, correct?

I would want to block the virus at the ACE2 receptor site.  This is the Holy Grail of preventing viral replication. 

Looks like Hesperidin might do this!  

I would want to block the virus at the ACE2 receptor site.  This is the Holy Grail of preventing viral replication. 

 

Looks like Hesperidin might do this!  

Based upon this study

Potential natural compounds for preventing 2019-nCoV infection  Hansen Chen, Qiaohui Du

The herb scutellarin (skullcap) was shown to have a higher affinity for binding to the ACE2 receptor to

block the virus.  It has a docking score of -14.9 which was better than Hesperdin.

"Here we conduct a molecular docking and find that scutellarin could bind to ACE2, with estimated ΔG (kcal/mol) -14.9,

with binding site GLU-495, UNK-957, ARG-482"

And it also has anti-viral properties for pneumonia and was being used over in China to treat Covid 19

https://link.springe...3020-019-0229-x

Hesperidin is available as a supplement, but orange juice is a natural source.  Interestingly, fresh frozen concentrate seems to have the highest hesperidin levels.  The hesperidin is in the rind, and the commercial orange crushers used to make commercial juice squeeze the fruit so hard that more hesperidin is released.

Thats why I eat citrus fruits always with the peel.

The highest content of hesperidin was actually found in tangelo juice at about 80 mg/gram. http://microbiomepre...Details?fid=759 - but I believe these numbers for fruits would be higher, if also the peels would have been taken into account. As is usual in concentrates. After all, by concentrating only water-weight is reduced.
 

What about royal jelly? Can help or exacerbate a cytokines storm?

My Spidey sense is tingling...  Did a real doctor just mention zinc? 

 

https://www.mediamat...-regimen-doctor

 

Sean Hannity reads Mike Pence a letter from unidentified doctor detailing a drug “regimen” the doctor claims prevents coronavirus deaths

 

"This (New York doctor) and his team have now treated approximately 350 patients in Kiryas Joel, it was an area of New York that was hit particularly hard and another 150 patients and other New York areas. 

 

"Hydroxychloroquine, 200 milligrams twice a day, five days. Azithromycin, 500 milligrams once a day, five days. Zinc sulfate, 220 milligrams once a day for five days"

 

"His results, we have had zero deaths, zero hospitalizations, zero intubations, zero."

 

Got Zinc?

Hahaha, boom!

The Netherlands to become the third country (after China and the US) to treat COVID-19 with plasma from recovered patients

https://www.ad.nl/do...geven~aef2de50/

Prince Charles has been diagnosed with COVID-19.

He is over 70 years old, yet he has only mild symptoms.

I found out what his bloodtype is: It's O negative.

https://news.sky.com...vid-19-11963363

Prince Charles has been diagnosed with COVID-19.

 

He is over 70 years old, yet he has only mild symptoms.

 

 

I found out what his bloodtype is: It's O negative.

 

https://news.sky.com...vid-19-11963363

A lot of royals are O-.  I have DNA/bloodlines back to King Edward I, my family hails from London, and I am O negative.

Here's some good news that makes sense.  I've been skeptical of the previous studies saying this will last 18 months and result in millions of death.  Frankly, it never passed the smell test.  Here's a recent study with much more realistic assumptions:

https://www.ft.com/c...df-41bea055720b

Basically, the idea is that the virus has already been around for a month earlier than previously thought, which dramatically changes the timeline of the epidemic.  It also confirms what we have seen in China and South Korea.

I've been wondering whether myself and parts of my family have already had it.  Certainly, I've had sore throat and cough, but that is not uncommon for me in winter.  We need that antibody test.

I've been trying to figure out the ACE2 enzyme connection myself.  The virus is supposed to enter cells to replicate through the ACE2 receptor.  

 

What I don't know is whether or not the ACE2 enzyme carries or guides the virus to the ACE2 receptor sites or not.  I'm kind of thinking this might be might be the case.  The virus doesn't have eyes, and the thought it might simply float around until it randomly bumped into a receptor sounds unlikely.  Something guides it to the receptor.  The ACE2 enzyme is a likely suspect.  

I don't thing an enzyme is needed for docking to a receptor. Rather, everything happens due to electromagnetic  interactions. Each molecule has a pattern of positive and negative charges, in a certain configuration. The receptor has the same configuration in opposite polarities. So when a molecule appears nearby, if it matches the reverse pattern of polarities, it snaps right in  onto receptor, like a magnetic clothing snap. 

New York hospitals are treating all coronavirus patients with high doses of IV VITAMIN C after promising results from China

https://www.dailymai...-VITAMIN-C.html

Dr Andrew Weber shared that he has been immediately giving his intensive-care patients 1,500 milligrams of intravenous vitamin C

The Long Island based pulmonologist and critical-care specialist with Northwell Health shared that patients are given three to four doses a day

Jason Molinet, a spokesman for Northwell, said that Vitamin C is being 'widely used' as a coronavirus treatment throughout the health system

Mass media news article:
 
Covid-19 Research Updates: Chinese Study Reveals That Hypokalemia Present In Almost All Covid-19 Patients
 
Paper on which that article is based:
 
Hypokalemia and Clinical Implications in Patients with Coronavirus Disease 2019 (COVID-19)

I realize it's simplistic, but does that mean upping your potassium might help during the infection phase?  Hard to say, but these things are so easy to do and safe that it's worth trying anyway.

oops, should have read the article first, they actually did supplement the patients with K+ and it did help... nice.

The hypokalema thing might also point to the exact type of hypertension that is more problematic.  I think aldosteronism has hypokalemia as a symptom.  So it may be this subtype, as opposed to sympathetic or other sub-types.

aldosterone pathway is also the culprit in greater hypertension among Black people.  But I haven't seen any reports of that group having greater susceptibility or worse outcomes.

The hypokalema thing might also point to the exact type of hypertension that is more problematic.  I think aldosteronism has hypokalemia as a symptom.  So it may be this subtype, as opposed to sympathetic or other sub-types.

 

aldosterone pathway is also the culprit in greater hypertension among Black people.  But I haven't seen any reports of that group having greater susceptibility or worse outcomes.

This is exactly correct.  The worst covid patients end up hypokalemic and their blood pressure is high.  It's dis-regulated RAS/aldosterone.

Lots of good data in the full paper, which also confirms the immuno-compromised theory. Lets not forget that the lifetime risk of hypertension is >90%, so using that as a proxy alone is fairly worthless and exactly the same as using aging as a proxy.