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My LIPIDS over the past year and a half on Keto vs Plant based

dietary approach lipids

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#31 RWhigham

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Posted Yesterday, 04:23 PM

What is the entirety of your Lipid context? What did your total cholesterol, LDL, HDL and trigs look like when receiving that measurement?

Lp(a) 6 nmol/L was only measured once on Sep 13, 2017.  TC at the time was elevated from bronchitis 276 mg/dL

What is your history?

After my cholesterol climbed to 220 circa 2000-2004, I became a vegetarian which dropped my TC to 170.

My CAC score 15 years ago and again 10 years ago stayed at 8 from one tiny spec of calcium reinforcing a sharp bend in one coronary artery. So appearing to be free of atherosclerosis, in 2008 I adopted a hi-fat low-carb diet to raise my cholesterol to around 240, which is reported give minimum mortality in men free of CHD. 

  • All measurements in mg/dL
  • Sep 30, 2014    TC  277    LDL-C  189    HDL-C 72   Trigs  81    Lipids elevated by low T4 thyroid level
  • Feb 3,   2015    TC  204    LDL-C  128    HDL-C 61   Trigs  74
  • Apr 23, 2017     TC 252     LDL-C 160     HDL-C 78   Trigs  71 
  • Sep 13, 2017    TC 276     LDL-C 195     HDL-C 60   Trigs  103   Lipids elevated by bronchitis
  • Aug 3,  2019     TC 210     LDL-C  124    HDL-C 73   Trigs   63
  • Oct 11, 2019     TC 241     LDL-C  152    HDL-C  68   Trigs 104   Trigs not fasted long enough

I consider the last results above to be ideal for minimum mortality provided one is free of heart disease. However my LDL-P count and "small-dense" LDL-P count (not shown) are high on this diet. This is common, concerning, and worrisome to everyone on this diet. No one can say how much of a problem it might be.

  • I usually eat only one meal between 11 am and 1pm to allow my cells plenty of time for house-keeping
  • I occasionally fast for one or two days, but meal time is a social occasion that I don't like to miss.
  • My current diet is high in dairy fat from 100% grass-fed cows.
  • I avoid fat from most pork and beef because it's likely unhealthy because of the animal's diet.
  • The fat from "life-time" grass-fed beef is acceptable and I always buy such beef with the highest percentage fat.
  • Note that just "grass-fed" says nothing about how long, could be only a few days.
  • Note that "free-range" chicken just means the coop had a door leading to an open space, often tiny.
  • I eat "pasture-raised" chicken, "life-time" grass-fed beef, "wild-caught" salmon & shrimp
  • I eat a medley of steamed veggies, green beans, broccoli, cauliflower, peas, bok choy, brussel sprouts, carrots.
  • I eat typical low-carb: no bread, potatoes, rice, cereal, alcohol, commercial salad dressings, soft drinks, fruit drinks, and only an occasional piece of fruit.
  • I only buy late-harvest olive oil in the spring when its fresh out of settling tanks with minimum light exposure and the highest polyphenol content I can find
  • I don't eat uncooked foods. I would eat salads if I could grow them myself, but not otherwise.

Edited by RWhigham, Yesterday, 04:41 PM.

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#32 aribadabar

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Posted Yesterday, 05:01 PM

... from a long list of expensive supplementation for many years...

 

Would you share its constituents and your personal assessment of them?



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#33 RWhigham

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Posted Yesterday, 05:47 PM

... from a long list of expensive supplementation for many years...

 

Would you share its constituents and your personal assessment of them?

 

Aug 2, 2020

7 am          T3 1 tab  5ug       T4 equivalence = 15ug x 2.875 + 67.86 ug = 111 ug  (for thyroidectomy)
                  T4  75ug 1.5 tab qd less 1 tab on Wed, 67.86 ug per day average 
                  Progest TD 20mg 1/4tsp to back of hands           +rejuv hands
                  Hekla Lava 1tsp & 4 pellets SL Calc Fluor 30c       +rejuv spine
                  Pu-erh tea,  1/8 htsp TMG  -homocysteine -IL-6/TNF-a/CRP -21/23/26% +immunity -cancer
9 am           M1 (morning) w 1/2 tsp hyaluronic ac in water               +skin/joints
After lunch  L1 (lunch) w  1/2 tsp Creatine, HMB, & Hyaluronic Ac in water +skin/joints/muscles
3  pm          T3 1 tab  5ug
5  pm          E1 (evening)  w  1/2 tsp hyaluronic ac in water                         +skin/joints
                   Pu-erh_Tea,  1 tsp inositol   -IL-6/TNF-a/CRP -21/23/26% +immunity  -cancer
6  pm          Hekla Lava 1tsp (1pellet 30c in 6oz water)            +rejuv spine
8  pm          N1 (night) 1/2 tsp Reishi 100:1 extract +mouse_lifespan 20% +telomerase 200% w candesartan
11 pm         T3 1 tab  5ug
 
M1 - morning
   Vit-A 10,000 iu (3mg)  1gel  syn w vit-D3 1:1 by iu   UL = 3mg  RDA = 0.7 mg
   Alpha Keto Glutaric Ac 2cap 600mg & Vit-A 10,000iu  +HDL  -TC/LDL  rejuv DNA_melthlation
   L_Reuteri_6475 1cap 3 billion CFU   +Oxytocin3x +Thymus2x  -Neutrophils/Stress-hormones
-  Methyl-B12 2.5mg SL (1/2 tab) Jarrow  -homocysteine
-  B-multi  1cap  Swanson "Active-B" 
-  Methy-Folate 5mg 1cap LEF -homocysteine  UL 15mg  (unlike folic acid where > 200ug is bad)
   Tadalafil  5mg (1/2tab)  -BPH +lifespan in Blagosklonny_protocol
   [MWF] Deprenyl (Seglegiline) 1.25mg (1/4 tab) +MAO-B to youthful level
 
E1 - evening
   IP6 2g 4cap halflife 1hr  -cancer/mTOR/iron +autophagy  +NK_cells_synergistic_inositol
 
M1 E1 - bid
   DIM_Plus 50mg 1cap -aromatase/p_C/BCL/mTOR +Autoph/DNA_repair w suforaphane, NAC, lipoic ac
   Wobenzyme (1tab) Pancreatic_enzymes & Rutin_75mg  -Hasini_effect/Metastasis/TGF-b1/Inflam/CRP
   ComfortMax  -TGF-b1/Inflam/aging PPARa-stim -pain
* DHA/EPA 1g/100mg 1gel Dr's_Best +Mem/Neurogen/telomerase/autophagy
   ALCAR 500mg 1cap  -Lipofusin/NF-kB/glycation +UPS/Mito/Mem/ACh  chromatin-expand  syn Centroph
   Centrophenoxine 250mg (1cap) -lipofucin_w_ALCAR   +memory/mRNA/Murine_life +27%
   Pycnogenol  95mg  1cap   -IL-6/TGF-b/Inflam/Athero +sox2 +Nrf2  syn w Gotu Kola/noCVD
   Gotu Kola 950mg (2cap) -ROCK/Tgf_b/Smad2,3/BP/P_cancer +Klf4/PPARg/Smad7/telomerase/neurogen
   Lycopene 1gel 15mg LYC-O-Mato  -DHT/P_cancer/BPH/NF-kB_35%  +Nrf2
   Glutathione 500mg (2cap)  DNA-protect  cytosol_antioxidant +telomerase
* CoQ10  100mg  1gel  -Ather -CHD 54% w Se  syn ALCAR  NOAEL=1200mg
   d-Tocotrienol (E) 125mg  1gel delta-gold  -TC_15%/VCAM1  +AMPK/lifespan
   MK7 90ug  1gel  Jarrow  (100ug MK7 per 5,000 D3 is mandatory)  +Ca_regulaion
-  P5P (B6) 50mg  1cap (P5P should not have neurotoxicity)  -homocysteine -glycation 
   Magtein M1 E2  (Mg 150mg & theonate 186mg in 3caps)  -DKK-1 +Wnt_sig/hippocamp_neurogen
   [1-3 Monthly] Quercetin EMIQ 50mg 1cap -nucCD38  ++nucNAD+  syn apigenin (caution: topo-poison)
   [1-7 & 15-21 Monthly] NK-Cell-Act LEF 1cap  +Immune_boost
 
M1 L1 E1 - tid
   Mg-bicarb 1/8tsp 300mg, Ribose 3mg, AscorbicAc 1/8tsp 150mg in 20cc warm H2O  -cancer
   Hyaluronic acid 1/2 tsp  (float then pour water on top)  +joints/dermis/youthfulness
   L-Carnosine 500mg 1cap  -glycation/TGF-b1/mTOR/Inflamaging DNA_protect +skin/brain2
-  Benfotiamine (B1) 150mg 1cap  -glycation -AGEs (advanced glycation end-products)
-  Riboflavin (B2) 100mg 1cap syn w vit-D3   -homocysteine
   Mg-Malate (Mg 425mg in 3caps)  syn CoQ10 & Selenium RDA 420mg  50% are deficient
   Astaxanthin 4mg 1gel  ++DNA_protect +FOXO3A -Athero/oxLDL/DNA_damage -40% [w Zeaxanthin,Lutein]
   Rhodiola 350mg 1cap  ++DNA_repair  -stress/MAO/BG     very hi dose can be toxic
   Horny GW icariin 100mg 1cap  -BPH/PAH/PDE5/TOR1/osteoporosis +T/BMD/stemcells/DNA-repair/mRNA
   Milk Thistle w tumeric (2cap tid) Natural Grocers  ++liver-protect +AMPK/lfespan
* Fo-Ti-Prep 16:1 500mg (2cap tid) +hair/youth/AMPK -amyloid/inflam/cancer  liver_tox_w/o_Prep
 
L1  - lunch
   DHEA 25mg 1cap  +telomerase TOR-stim Autoph-inh  -old_age  goal 300 ug/dL
   Pregnenolone 50mg 1cap +telomerase TOR-stim Autoph-inh -old_age goal 166 ng/dL
   Stinging Nettle root 750mg 1cap -BPH/estradiol/aromatase
   Heliocare Polypodium L. 240mg 1cap +p53/tgf-b/lungs/skin  -IL-6/CRP/C/HasiniMetastasis  halfife 4-6hr  
   Lutein 4 mg  in 1gel LEF_MacuGuard -NF-kB +Nrf2  -DNA_damage_40% w Astaxanthin
   Zeaxanthin 1.34mg  in 1gel LEF_MacuGuard
   Saffron ext 20mg in 1gel LEF_MacuGuard  telomerase_inh
   Oleuropein 100mg 1cap Swanson OLE ++UPS +HDL/Nrf2/PPARa//AMPK -LDL/oxLDL/LPS/NF_kb/cell_debris
   Ginkgo 1cap 120mg +DNA_repair/NO/m_life+8%/estrogenic  -inflam/CRP/cortisol/NF-kB/MPO/cancer/oxLDL
   Alpha Lipoic Acid TR 300mg 1tab -LPS/lipofucin/abdomial_fat Releases_Hg needs_NAC to remove Hg
   NAC TR 600mg 1cap  -Hg/lung_mucus/NF-kB/IGF-1 +glutathione/Murine_life +40% needs 2g vit-C TR
* White Willow Bark 75mg salicin 1cap DNA_protect TOR-inh +AMPK/lifespan +Sirt1 -tumors_10-fold
* DHA/EPA_250/350 1gel LEF_Super_Omega3 -LPS/TNF-a/NF-kB/CRP/C/mTOR/Bcl
   Vit-C TR 1g 1tab  -Athero Anti-ox  Autoph-inh -Lp chromatin-expand to enable telomerase
   Vit-D3 5,000 iu 1gel  (100ug MK7 per 5k D3 reqd for Ca_reg) 10k/day D3 ruined my nails
   Vit-K  K1-5mg MK4-25mg MK7-500ug Astaxanthin 2mg   (1cap  Koncentrrated-K)
   Zinc-L-carnosine 16mg (2cap) RDA 11mg -CRP/LPS/BG/reflux/gut_leakage  -Cu  +Nrf2
   Selenium 100ug 1cap -Ather Anti-ox  Typ Food100ug Optimum 200ug UL400ug
   Boron 3mg 1cap CRP -50% IL-6 -44% TNFa -30%  freeT+28%  +estradiol_if_too_much
   Iodine  225ug 1tab potassium_iodine Now Foods
   [MWF]   Molybdenum 150ug  1 tab 
   [MWF]   Manganese  2.5mg (1/4 tab)  hi-in-US-food  AI 2.3mg   excess-is-highly-toxic
   [1-3 & 15-17 Monthly] Cistanche 210mg  1cap LEF  +DNA_repair/Immune_boost
 * blood thinner
 
N1  - night
   Melatonin 200mg (Bulk supplements powder)  -LH/fasting_insulin +thymus  CR_mimetic
   DHEA 50mg (2cap)  +telomerase TOR-stim Autoph-inh  -old_age  goal 300 ug/dL
   Pregnenolone 50mg 1cap +telomerase TOR-stim Autoph-inh -old_age goal 166 ng/dL
   Probiotic w phages 1cap PreForPro -LPS +lifespan
   Chromium picolinate 200ug 1cap Now Foods  -Fasting Glucose +insulin  if deficient (rare)
   OPC_GSE 150mg (2tab) +nucNAD+/Sirt1/Nampt/FOXO3/PINK1/PARKIN/lifespan -estradiol/BPH/tau/mTOR
   Lithium 5mg 1tab  +nucNAD+ (oppsite am) +Nampt/neural-protect/AMPK/lifespan -Alz/inflam
   Rhodiola 350mg 1cap -stress/MAO/BG +DNArepair
   Schizandra 500mg 9% 1 cap  -stress, balance para & sympa w/eleuthero
   Siberian Eleuthero 500mg (5:1)  1cap  -stress, +T-cells +cognition
   Pycnogenol  95mg  1cap   -IL-6/TGF-b/Inflam/Athero +sox2 +Nrf2  syn w Gotu Kola/noCVD
   TRU Niagen 300mg 1cap NR  needs_TMG  +DNA_repair/NAD+/mitogenesis  -IL-2/IL-5/IL-6 
   Methylene_blue 1g (1/4 tsp of diution) +Mitos/complex_IV -C  -alt_splicing_error/senescence
   LDN 2.5mg (3 squirts) +endorphins/immune_function/libedo -C/inflam/pain
   [Wed] Ashwagandha KSM66 2.1g (7cap) rap_mimetic  -cancer/NF-kb +Nrf2/telomeres
   [1st day of Month] Apigenin 250mg (5caps) -nucCD38 ++nucNAD+ syn quercetin (caution: topo-poison)
   [15th day of Month] Fisetin 1.2g 12 cap -senescent cells +osteoblasts  (caution: topo-poison)
   [15th day of Month] Quercetin 1g 2cap  (caution: topo-poison)   synergistic Fisetin
 
Hyaluronic acid for joints may also help maintain the glycocalyx lining of arteries and help prevent it from being dissapated by elevated postprandial blood sugar. To take hyaluronic acid, I put a half tsp on top of a cup of water, then pour more water on top of it to wet it, then spoon out the glutinous mass with a tablespoon.

Edited by RWhigham, Yesterday, 06:18 PM.

  • Informative x 2

#34 pamojja

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Posted Yesterday, 08:12 PM

I'm surprised you take only 1 meal, and stomach so many w/meal supplements on an empty stomach.



#35 aribadabar

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Posted Yesterday, 09:42 PM

 

Aug 2, 2020

7 am          T3 1 tab  5ug       T4 equivalence = 15ug x 2.875 + 67.86 ug = 111 ug  (for thyroidectomy)
                  T4  75ug 1.5 tab qd less 1 tab on Wed, 67.86 ug per day average 
                  Progest TD 20mg 1/4tsp to back of hands           +rejuv hands
                  Hekla Lava 1tsp & 4 pellets SL Calc Fluor 30c       +rejuv spine
                  Pu-erh tea,  1/8 htsp TMG  -homocysteine -IL-6/TNF-a/CRP -21/23/26% +immunity -cancer
9 am           M1 (morning) w 1/2 tsp hyaluronic ac in water               +skin/joints
After lunch  L1 (lunch) w  1/2 tsp Creatine, HMB, & Hyaluronic Ac in water +skin/joints/muscles
3  pm          T3 1 tab  5ug
5  pm          E1 (evening)  w  1/2 tsp hyaluronic ac in water                         +skin/joints
                   Pu-erh_Tea,  1 tsp inositol   -IL-6/TNF-a/CRP -21/23/26% +immunity  -cancer
6  pm          Hekla Lava 1tsp (1pellet 30c in 6oz water)            +rejuv spine
8  pm          N1 (night) 1/2 tsp Reishi 100:1 extract +mouse_lifespan 20% +telomerase 200% w candesartan
11 pm         T3 1 tab  5ug
 
M1 - morning
   Vit-A 10,000 iu (3mg)  1gel  syn w vit-D3 1:1 by iu   UL = 3mg  RDA = 0.7 mg
   Alpha Keto Glutaric Ac 2cap 600mg & Vit-A 10,000iu  +HDL  -TC/LDL  rejuv DNA_melthlation
   L_Reuteri_6475 1cap 3 billion CFU   +Oxytocin3x +Thymus2x  -Neutrophils/Stress-hormones
-  Methyl-B12 2.5mg SL (1/2 tab) Jarrow  -homocysteine
-  B-multi  1cap  Swanson "Active-B" 
-  Methy-Folate 5mg 1cap LEF -homocysteine  UL 15mg  (unlike folic acid where > 200ug is bad)
   Tadalafil  5mg (1/2tab)  -BPH +lifespan in Blagosklonny_protocol
   [MWF] Deprenyl (Seglegiline) 1.25mg (1/4 tab) +MAO-B to youthful level
 
E1 - evening
   IP6 2g 4cap halflife 1hr  -cancer/mTOR/iron +autophagy  +NK_cells_synergistic_inositol
 
M1 E1 - bid
   DIM_Plus 50mg 1cap -aromatase/p_C/BCL/mTOR +Autoph/DNA_repair w suforaphane, NAC, lipoic ac
   Wobenzyme (1tab) Pancreatic_enzymes & Rutin_75mg  -Hasini_effect/Metastasis/TGF-b1/Inflam/CRP
   ComfortMax  -TGF-b1/Inflam/aging PPARa-stim -pain
* DHA/EPA 1g/100mg 1gel Dr's_Best +Mem/Neurogen/telomerase/autophagy
   ALCAR 500mg 1cap  -Lipofusin/NF-kB/glycation +UPS/Mito/Mem/ACh  chromatin-expand  syn Centroph
   Centrophenoxine 250mg (1cap) -lipofucin_w_ALCAR   +memory/mRNA/Murine_life +27%
   Pycnogenol  95mg  1cap   -IL-6/TGF-b/Inflam/Athero +sox2 +Nrf2  syn w Gotu Kola/noCVD
   Gotu Kola 950mg (2cap) -ROCK/Tgf_b/Smad2,3/BP/P_cancer +Klf4/PPARg/Smad7/telomerase/neurogen
   Lycopene 1gel 15mg LYC-O-Mato  -DHT/P_cancer/BPH/NF-kB_35%  +Nrf2
   Glutathione 500mg (2cap)  DNA-protect  cytosol_antioxidant +telomerase
* CoQ10  100mg  1gel  -Ather -CHD 54% w Se  syn ALCAR  NOAEL=1200mg
   d-Tocotrienol (E) 125mg  1gel delta-gold  -TC_15%/VCAM1  +AMPK/lifespan
   MK7 90ug  1gel  Jarrow  (100ug MK7 per 5,000 D3 is mandatory)  +Ca_regulaion
-  P5P (B6) 50mg  1cap (P5P should not have neurotoxicity)  -homocysteine -glycation 
   Magtein M1 E2  (Mg 150mg & theonate 186mg in 3caps)  -DKK-1 +Wnt_sig/hippocamp_neurogen
   [1-3 Monthly] Quercetin EMIQ 50mg 1cap -nucCD38  ++nucNAD+  syn apigenin (caution: topo-poison)
   [1-7 & 15-21 Monthly] NK-Cell-Act LEF 1cap  +Immune_boost
 
M1 L1 E1 - tid
   Mg-bicarb 1/8tsp 300mg, Ribose 3mg, AscorbicAc 1/8tsp 150mg in 20cc warm H2O  -cancer
   Hyaluronic acid 1/2 tsp  (float then pour water on top)  +joints/dermis/youthfulness
   L-Carnosine 500mg 1cap  -glycation/TGF-b1/mTOR/Inflamaging DNA_protect +skin/brain2
-  Benfotiamine (B1) 150mg 1cap  -glycation -AGEs (advanced glycation end-products)
-  Riboflavin (B2) 100mg 1cap syn w vit-D3   -homocysteine
   Mg-Malate (Mg 425mg in 3caps)  syn CoQ10 & Selenium RDA 420mg  50% are deficient
   Astaxanthin 4mg 1gel  ++DNA_protect +FOXO3A -Athero/oxLDL/DNA_damage -40% [w Zeaxanthin,Lutein]
   Rhodiola 350mg 1cap  ++DNA_repair  -stress/MAO/BG     very hi dose can be toxic
   Horny GW icariin 100mg 1cap  -BPH/PAH/PDE5/TOR1/osteoporosis +T/BMD/stemcells/DNA-repair/mRNA
   Milk Thistle w tumeric (2cap tid) Natural Grocers  ++liver-protect +AMPK/lfespan
* Fo-Ti-Prep 16:1 500mg (2cap tid) +hair/youth/AMPK -amyloid/inflam/cancer  liver_tox_w/o_Prep
 
L1  - lunch
   DHEA 25mg 1cap  +telomerase TOR-stim Autoph-inh  -old_age  goal 300 ug/dL
   Pregnenolone 50mg 1cap +telomerase TOR-stim Autoph-inh -old_age goal 166 ng/dL
   Stinging Nettle root 750mg 1cap -BPH/estradiol/aromatase
   Heliocare Polypodium L. 240mg 1cap +p53/tgf-b/lungs/skin  -IL-6/CRP/C/HasiniMetastasis  halfife 4-6hr  
   Lutein 4 mg  in 1gel LEF_MacuGuard -NF-kB +Nrf2  -DNA_damage_40% w Astaxanthin
   Zeaxanthin 1.34mg  in 1gel LEF_MacuGuard
   Saffron ext 20mg in 1gel LEF_MacuGuard  telomerase_inh
   Oleuropein 100mg 1cap Swanson OLE ++UPS +HDL/Nrf2/PPARa//AMPK -LDL/oxLDL/LPS/NF_kb/cell_debris
   Ginkgo 1cap 120mg +DNA_repair/NO/m_life+8%/estrogenic  -inflam/CRP/cortisol/NF-kB/MPO/cancer/oxLDL
   Alpha Lipoic Acid TR 300mg 1tab -LPS/lipofucin/abdomial_fat Releases_Hg needs_NAC to remove Hg
   NAC TR 600mg 1cap  -Hg/lung_mucus/NF-kB/IGF-1 +glutathione/Murine_life +40% needs 2g vit-C TR
* White Willow Bark 75mg salicin 1cap DNA_protect TOR-inh +AMPK/lifespan +Sirt1 -tumors_10-fold
* DHA/EPA_250/350 1gel LEF_Super_Omega3 -LPS/TNF-a/NF-kB/CRP/C/mTOR/Bcl
   Vit-C TR 1g 1tab  -Athero Anti-ox  Autoph-inh -Lp chromatin-expand to enable telomerase
   Vit-D3 5,000 iu 1gel  (100ug MK7 per 5k D3 reqd for Ca_reg) 10k/day D3 ruined my nails
   Vit-K  K1-5mg MK4-25mg MK7-500ug Astaxanthin 2mg   (1cap  Koncentrrated-K)
   Zinc-L-carnosine 16mg (2cap) RDA 11mg -CRP/LPS/BG/reflux/gut_leakage  -Cu  +Nrf2
   Selenium 100ug 1cap -Ather Anti-ox  Typ Food100ug Optimum 200ug UL400ug
   Boron 3mg 1cap CRP -50% IL-6 -44% TNFa -30%  freeT+28%  +estradiol_if_too_much
   Iodine  225ug 1tab potassium_iodine Now Foods
   [MWF]   Molybdenum 150ug  1 tab 
   [MWF]   Manganese  2.5mg (1/4 tab)  hi-in-US-food  AI 2.3mg   excess-is-highly-toxic
   [1-3 & 15-17 Monthly] Cistanche 210mg  1cap LEF  +DNA_repair/Immune_boost
 * blood thinner
 
N1  - night
   Melatonin 200mg (Bulk supplements powder)  -LH/fasting_insulin +thymus  CR_mimetic
   DHEA 50mg (2cap)  +telomerase TOR-stim Autoph-inh  -old_age  goal 300 ug/dL
   Pregnenolone 50mg 1cap +telomerase TOR-stim Autoph-inh -old_age goal 166 ng/dL
   Probiotic w phages 1cap PreForPro -LPS +lifespan
   Chromium picolinate 200ug 1cap Now Foods  -Fasting Glucose +insulin  if deficient (rare)
   OPC_GSE 150mg (2tab) +nucNAD+/Sirt1/Nampt/FOXO3/PINK1/PARKIN/lifespan -estradiol/BPH/tau/mTOR
   Lithium 5mg 1tab  +nucNAD+ (oppsite am) +Nampt/neural-protect/AMPK/lifespan -Alz/inflam
   Rhodiola 350mg 1cap -stress/MAO/BG +DNArepair
   Schizandra 500mg 9% 1 cap  -stress, balance para & sympa w/eleuthero
   Siberian Eleuthero 500mg (5:1)  1cap  -stress, +T-cells +cognition
   Pycnogenol  95mg  1cap   -IL-6/TGF-b/Inflam/Athero +sox2 +Nrf2  syn w Gotu Kola/noCVD
   TRU Niagen 300mg 1cap NR  needs_TMG  +DNA_repair/NAD+/mitogenesis  -IL-2/IL-5/IL-6 
   Methylene_blue 1g (1/4 tsp of diution) +Mitos/complex_IV -C  -alt_splicing_error/senescence
   LDN 2.5mg (3 squirts) +endorphins/immune_function/libedo -C/inflam/pain
   [Wed] Ashwagandha KSM66 2.1g (7cap) rap_mimetic  -cancer/NF-kb +Nrf2/telomeres
   [1st day of Month] Apigenin 250mg (5caps) -nucCD38 ++nucNAD+ syn quercetin (caution: topo-poison)
   [15th day of Month] Fisetin 1.2g 12 cap -senescent cells +osteoblasts  (caution: topo-poison)
   [15th day of Month] Quercetin 1g 2cap  (caution: topo-poison)   synergistic Fisetin
 
Hyaluronic acid for joints may also help maintain the glycocalyx lining of arteries and help prevent it from being dissapated by elevated postprandial blood sugar. To take hyaluronic acid, I put a half tsp on top of a cup of water, then pour more water on top of it to wet it, then spoon out the glutinous mass with a tablespoon.

 

 

Thank you so much for the detailed response!

I have a few questions on certain items:

 

 

 

   L_Reuteri_6475 1cap 3 billion CFU   +Oxytocin3x +Thymus2x  

 

I know only of 100M CFU L.reuteri 6475 caps commercially available - would you point me to the 3B CFU per cap product?

 

What is the form of Oxytocin used?

Thymus=?? Thymus glandular extract?

 

 

 

Wobenzyme (1tab) 

 

The recommended daily dosage is at least 3 caps ( up to 12) . What is your rationale for taking only 1/3 of the minimum?

 

 

 

ALCAR 500mg 1cap  -Lipofusin/NF-kB/glycation +UPS

 

What does UPS stand for?

 

 

 

NK-Cell-Act LEF 

 

Isn't LEF's "proprietary blend of modified rice bran" in this product the BetaRight glucans extract?

 

 

 

CoQ10  100mg  

 

Isn't this a bit too low of a dose? Especially if it is the regular ubiquinone form for someone 50+.

 

 

 

Methylene_blue 1g 

 

1g? Isn't that a toxic high dose? I see doses in the 100mg range as the upper level.

 

 

-  Methyl-B12 2.5mg SL (1/2 tab) 

-  B-multi  1cap  Swanson "Active-B" - containing  R5P 25 mg , P5P 25 mg ,Folate 400 mcg , Benfotiamine 36 mg

-  Methy-Folate 5mg 
- P5P (B6) 50mg  1cap 
- Benfotiamine (B1) 150mg 
- Riboflavin (B2) 100mg 

 What is the rationale for such high level intakes of B1, B2, B6? Commensurate doses serving as cofactors of the high doses of B9 and B12 for lowering homocysteine?

 

 

Milk Thistle w tumeric (2cap tid) Natural Grocers  ++liver-protect +AMPK/lfespan

 

FWIW you may consider TUDCA as liver tonic.

 

 

 

   Vit-C TR 1g

 

What TR form of vit C is this? PureWay-C?

 

Thanks for your insight!



#36 RWhigham

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Posted Yesterday, 11:16 PM

Responding to Aribadabar's queries in the preceeding post:

  • L_reuteri 6475 with 10 billion CFU is  BioGaia Ostofortis
  • The "+oxytocin3x" after the L-reuteri means the L-reuteri raises oxytocin levels three fold. While not listed, I also use an OxyPure nasal spray two squirts in each side 1st thing in the morning, but its unlikely to be effective.
  • I take a Wobenzyme tab (M1 and E1 meaning in the morning and evening) 1/3 the recommended dose because the recommended dose gives me heartburn.
  • ALCAR "+UPS" is a Ubiquitin Proteasome System stimulant, the only one I know of. The UPS eliminates junk proteins from a cell.
  • LEF NK-Cell Activator is a "Proprietary Enzymatically Modified Rise Bran". I don't know if its related to beta glucans.
  • CoQ10 100mg is in the "M1  E1 bid" group taken in the morning and evening. 200 mg/d reduces CHD 54% provided selenium is in the proper range.
  • Methylene blue 1g/d is not a toxic dose. See discussion at the end of this list
  • B1 150mg tid in the form of benfotiamine may reduce glycation damage like L-carnosine. L-carnosine appears to reduce the rate of aging by reducing glycation. Benfotiamine may have a similar effect.
  • B2 (riboflavin) 100mg tid. I don't recall why I added this. The - sign in front of all the B vitamins in my list is a flag to reconsider & possibly eliminated them. The * is a flag indicating anti-coagulant effects. It's easy to combine too many anticoagulants so I keep track.
  • B6 in the form of P5P 50mg bid. This gives me the UL = 100mg/d  I take the UL dose of P5P for anti-glycation effect. The pyridoxine common in multi-vitamins is dangerous, but P5P should be very safe.
  • I'll take another look a TUDCA for liver support. I take a lot of Milk Thistle for liver support because with so many supplements my liver may need help. I usually get a chemistry panel blood test twice yearly, but Covid has kept me at home this year.
  • The Vit-C TR 1g tid is from Now Foods. I find I tolerate a larger dose of vit-C in the Time Release form.
Methylene blue is effective at 100 nM/L. It's molar wt is 320g/M x 100nM/L = 32 ug/L. I have about 11 L of extracellular liquid (Interstitial fluids, ECM extracellular matrix fluids) and 22 L of intracellular fluid.  Dose for 100 nM/L is therefore:
5 L x 32 ug/L = 160 ug for just blood.  11 L x 32 ug/L = 352 ug for extracellular fluids, 22L x 32 ug/L = 704 ug for intracellular fluid, and 1,054 ug for both.

Edited by RWhigham, Yesterday, 11:40 PM.

  • Informative x 1

#37 aribadabar

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Posted Today, 12:11 AM

 

Responding to Aribadabar's queries in the preceeding post:

  • L_reuteri 6475 with 10 billion CFU is  BioGaia Ostofortis
  • The "+oxytocin3x" after the L-reuteri means the L-reuteri raises oxytocin levels three fold. While not listed, I also use an OxyPure nasal spray two squirts in each side 1st thing in the morning, but its unlikely to be effective.
  • I take a Wobenzyme tab (M1 and E1 meaning in the morning and evening) 1/3 the recommended dose because the recommended dose gives me heartburn.
  • ALCAR "+UPS" is a Ubiquitin Proteasome System stimulant, the only one I know of. The UPS eliminates junk proteins from a cell.
  • LEF NK-Cell Activator is a "Proprietary Enzymatically Modified Rise Bran". I don't know if its related to beta glucans.
  • CoQ10 100mg is in the "M1  E1 bid" group taken in the morning and evening. 200 mg/d reduces CHD 54% provided selenium is in the proper range.
  • Methylene blue 1g/d is not a toxic dose. See discussion at the end of this list
  • B1 150mg tid in the form of benfotiamine may reduce glycation damage like L-carnosine. L-carnosine appears to reduce the rate of aging by reducing glycation. Benfotiamine may have a similar effect.
  • B2 (riboflavin) 100mg tid. I don't recall why I added this. The - sign in front of all the B vitamins in my list is a flag to reconsider & possibly eliminated them. The * is a flag indicating anti-coagulant effects. It's easy to combine too many anticoagulants so I keep track.
  • B6 in the form of P5P 50mg bid. This gives me the UL = 100mg/d  I take the UL dose of P5P for anti-glycation effect. The pyridoxine common in multi-vitamins is dangerous, but P5P should be very safe.
  • I'll take another look a TUDCA for liver support. I take a lot of Milk Thistle for liver support because with so many supplements my liver may need help. I usually get a chemistry panel blood test twice yearly, but Covid has kept me at home this year.
  • The Vit-C TR 1g tid is from Now Foods. I find I tolerate a larger dose of vit-C in the Time Release form.
Methylene blue is effective at 100 nM/L. It's molar wt is 320g/M x 100nM/L = 32 ug/L. I have about 11 L of extracellular liquid (Interstitial fluids, ECM extracellular matrix fluids) and 22 L of intracellular fluid.  Dose for 100 nM/L is therefore:
5 L x 32 ug/L = 160 ug for just blood.  11 L x 32 ug/L = 352 ug for extracellular fluids, 22L x 32 ug/L = 704 ug for intracellular fluid, and 1,054 ug for both.

 

 

Thank you for addressing them all, much appreciated!

 

As to methylene blue's dosage - I think you are missing an "m" then - 1mg/d of MB - as 1000ug =1mg, not 1g. That makes sense now. 1g/d is 1000x higher and definitely fatal

 

 

 

Methylene blue due to its monoamine oxidase(MAO) inhibiting property may precipitate potentially fatal serotonin toxicity at doses >5mg/kg

  • Agree x 1

#38 aribadabar

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Posted Today, 02:11 AM

It's surprising that a few pleiotropic compounds, that also have cardiovascular benefits, are missing from this otherwise exceptionally comprehensive stack:

 

  • Lysine - collagen synthesis, HSV suppression, endothelial function, joints help
  • Taurine - NO release regulation, endothelial function, exercise performance booster, nervous system nutrient
  • Glucosamine - autophagy, CVD risk/inflammation reduction, joints help 
  • Glycine - collagen synthesis, anti-inflammatory, helps against sarcopenia, potential sleep improvement if taken at night

 

Not sure if you've considered them already and if you did  it would be interesting to learn why you decided against them.

 

Thanks!







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