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PAYWALLED__Niacin Cures Systemic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy

niacin nad+ vitamin b3 nad+ repletion mitochondrial myopathy mtdna deletion mitochondria mitochondria treatment respiratory chain deficiency mitochondrial disease

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#1 Engadin

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Posted 10 May 2020 - 08:25 PM


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P A Y W A L L E D   S O U R C E :   Cell Metabolism

 

 

 

 

 

Highlights
 
  •  Mitochondrial myopathy patients have NAD+ deficiency in muscle and blood
 
  •  Niacin is an efficient NAD+ booster in humans
 
  •  Niacin improves muscle strength and fatty liver in mitochondrial myopathy
 
  •  Niacin boosts muscle mitochondrial biogenesis and respiratory chain activity in humans
 
 
 
Summary
 
NAD+ is a redox-active metabolite, the depletion of which has been proposed to promote aging and degenerative diseases in rodents. However, whether NAD+ depletion occurs in patients with degenerative disorders and whether NAD+ repletion improves their symptoms has remained open.
 
Here, we report systemic NAD+ deficiency in adult-onset mitochondrial myopathy patients. We administered an increasing dose of NAD+-booster niacin, a vitamin B3 form (to 750–1,000 mg/day; clinicaltrials.gov NCT03973203) for patients and their matched controls for 10 or 4 months, respectively. Blood NAD+ increased in all subjects, up to 8-fold, and muscle NAD+ of patients reached the level of their controls.
 
Some patients showed anemia tendency, while muscle strength and mitochondrial biogenesis increased in all subjects. In patients, muscle metabolome shifted toward controls and liver fat decreased even 50%. Our evidence indicates that blood analysis is useful in identifying NAD+ deficiency and points niacin to be an efficient NAD+ booster for treating mitochondrial myopathy.
 
 
 
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#2 SearchingForAnswers

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Posted 19 May 2020 - 07:05 PM

So, mayhaps we need not expensive Niagen to restore NAD+?



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#3 Engadin

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Posted 08 June 2020 - 07:35 PM

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"Niacin Increases NAD+ Significantly in Human Trial" @ LEAF (Life Extension Advocacy Foundation)

 

 

O P E N   A C C E S S   F U L L   T E X T  (.pdf) @ Cell Metabolism

 

 

 

 

 

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Also tagged with one or more of these keywords: niacin, nad+, vitamin b3, nad+ repletion, mitochondrial myopathy, mtdna deletion, mitochondria, mitochondria treatment, respiratory chain deficiency, mitochondrial disease

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