Hey guys,
I just want to know if I am interpreting this correctly. I am taking Tianeptine for its antidepressive activity which is related to its glutamatergic effects. If caffeine interferes with Tianeptines glutamatergic activity this would mean it could potentially diminish the antidepressive properties.
In recent work, Uzbay and colleagues found that tianeptine attenuated pentylenetetrazole (PTZ)-induced seizures [196,197,198] in rodents, which is consistent with its known mode of action to reduce excessive glutamatergic activity. Importantly, the investigators found that the latter effect was blocked by the administration of caffeine, a nonspecific adenosine receptor antagonist, and 8-cyclopentyl-1,3-dipropylxanthine, an A1 receptor-specific antagonist.