I have Pyritinol and am taking 200 mg a day. I feel that Pyritinol is relatively safe] supplement. I've read some studies that claim Hydergine helps protect the blood-brain barrier, and helps protect the brain from blood absence/surplus. I'm aware that Hydergine is mostly used for treating patients with dementia. I have also read that the supplement produced no different results than the placebo group (http://www.drugs.com..._Mesylates.html).
I'm just wondering if you all could help me out in making a sound decision 
Ergoloid mesylate for a healthy 20 year old....if your a healthy 20 year old then leave it at that. The "striving for more than you have when you are already healthy" mindset is a dangerous one. Especially when you are talking about taking medications. You could easily push yourself over the edge
I have Pyritinol and am taking 200 mg a day. I feel that Pyritinol is relatively safe, based off of all the empirical evidence that is available.
There are some case studies with pyritinol that suggest it may be problematic.
have a read of
this post
However, I'm not quite sure about this Hydergine [Co-dergocrine Mesylate (Ergoloid Mesylate)] supplement. I've read some studies that claim Hydergine helps protect the blood-brain barrier, and helps protect the brain from blood absence/surplus.
I don't think that you are going to find any real conclusive studies supporting the use of hydergine in healthy people. Heck, there aren't that many studies that conclude significant effect with hydergine with dementia. I use hydergine on occasions but will probably stop when my stash is finished.
Re. low blood pressure. I have fairly low blood pressure (BP as low as 95/60, heart rate~45-50bpm) but do have any problems. I do not have problems exercising or with my daily tasks. I do however on the rare occasion (once in a blue moon) stand up to quick and get a little dizzy but this is only when I am fatigued. Low blood pressure is not usually a problem unless it effects your everyday function. It may also be a problem if you have problems getting blood to your peripheral regions such as the hands. A healthy person should have a cardiovascular system efficient enough to function with low blood pressure.
If you are thinking about using a supplement that you think may lower your blood pressure and cause problems then consult your doctor and take the supplement under his supervision.
the one999 said:
Well it depends on your phsyical condition really. So if you're in great physical shape and fitness then it may not be a good idea since your baseline BMP & pressure will be lower than average. But if you're overweight, sedentary and eat a lot of junk food then maybe you could take it.
His physical condition is a healthy 20 year old.
hydergine is a fairly potent vasodilator which lowers blood pressure.
Apart from what is written on the label, can you provide a reference to back this statement. Even if hydergine is a potent vasodilator there is no conclusive evidence that this vasodilation results increased alterness or cognitive function in healthy subjects.
Hydergine for dementia.
Olin J, Schneider L, Novit A, Luczak S.
Adult and Geriatric Treatment and Preventative Interventions Branch, National Institute of Mental Health, NIMH, Room 7160, MSC 9635, 6001 Executive Blvd., Bethesda, Maryland, 20892-9635, USA. jolin@mail.nih.gov
BACKGROUND: Currently hydergine is used almost exclusively for treating patients with either dementia, or 'age-related' cognitive symptoms. Since the early eighties there have been over a dozen more clinical trials, yet hydergine's efficacy remains uncertain. Although previous reviews offer generally favorable support for hydergine's efficacy, they were, however, limited by a bias with respect to the particular clinical studies chosen (eg, the inclusion of case reports, and uncontrolled trials), and by authors' impressionistic assessments of results. Not surprisingly, there has been a lack of consensus among reviewers with regard to the efficacy of hydergine. In 1994, a meta-analysis was published by the present reviewers who reported that overall, hydergine was more effective than placebo. However they also observed that the statistical evidence for efficacy in 'possible or probable Alzheimer's disease' patients was so modest that one additional statistically non-significant trial would have reduced the results to non significance. OBJECTIVES: Because of uncertainty surrounding the efficacy of hydergine, the goals of this overview were to assess its overall effect in patients with possible dementia, and to investigate potential moderators of an effect. SEARCH STRATEGY: The trials were identified from a search of the Specialised Register of the Cochrane Dementia and Cognitive Improvement Group on 15 November 2000 using the terms hydergin*, ergoloid* and dihydroergo*. Two proprietary databases were searched also. Published reviews were inspected for further sources. SELECTION CRITERIA: Trials to be included must be randomized, double-blind, parallel-group, and unconfounded comparisons of hydergine with placebo for a treatment duration of greater than 1 week in subjects with dementia or symptoms consistent with dementia. DATA COLLECTION AND ANALYSIS: Data were extracted independently by the reviewers, pooled where appropriate and possible, and the pooled odds ratios (95%CI) or the average differences (95%CI) were estimated. Where possible, intention-to-treat data were used. Outcomes of interest included clinical global impressions of change and comprehensive rating scales. Potential moderating variables of a treatment effect included: inpatient/outpatient status, trial duration, age, sex, medication dose, publication year, and diagnostic grouping. MAIN RESULTS: There were a total of nineteen trials that met inclusion criteria and that had data sufficient for analysis. Thirteen trials reported sufficient information to use a global rating of improvement and nine trials provided information on a comprehensive rating scale. Three trials provided both outcome measures. It was not possible to use many of the published results in a combined analysis owing to the lack of sufficient data to perform statistical analyses. For the twelve trials that used global ratings, there was a significant effect favoring hydergine (OR 3.78, 95%CI, 2.72-5.27). For the nine trials that used comprehensive ratings, there was a significant mean difference favoring hydergine (WMD 0.96, 95%CI, 0.54-1.37). Hydergine was well tolerated in these trials, with 78% of randomized subjects available for data analyses. Greater effect sizes on global ratings were associated with younger age, and possibly higher dose, although most of the subgroup analyses were statistically insignificant. REVIEWER'S CONCLUSIONS: As in an earlier systematic review, we found hydergine to show significant treatment effects when assessed by either global ratings or comprehensive rating scales (based here on a smaller set of trials than in the earlier published systematic review because trials were required to have data that could conform with MetaView, the Cochrane Collaboration statistics software). The small number of trials available for analysis, however, limited the ability of subgroup analyses to identify statistically significant moderating effects. Unfortunately, most of the randomized, double-blind, and placebo-controlled trials of hydergine were conducted and published before the advent of consensus-based diagnostic standards of dementia in 1984; therefore diagnostic criteria were less specific. As a result, uncertainty remains regarding hydergine's efficacy in dementia.
Publication Types:
* Review
PMID: 11405961 [PubMed - indexed for MEDLINE]
haga11az, you could probably spend you well earned dollars on something that is IMO better than hydergine.
Have a read about the benefits of adaptogens such as rhodiola.
Here is a great monograph/review on Rhodiola
