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Small Molecule Dihexa-like Drug Approved for Phase II/III clinical trial

dihexa analog nootropic clinical trial

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#1 Targz

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Posted 25 July 2020 - 05:17 PM


Recently, an orally active drug with the same MOA as Dihexa, NDX-1017, got approved for a phase II/III clinical trial. Interested to see where this goes.

 

https://www.biospace...inancing-round/

 

I can't find much about it, not even a structure. Anyone else able to find anything?


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#2 megatron

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Posted 27 July 2020 - 02:01 PM

Where did you get it's orally active? In the phase 1 clinical trial they delivered the drug via subcutaneous injections.  

 

From the page linked above: "Athira Pharma was founded to commercialize the technology, and further development (of Dihexa) led to NDX-1017" 


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#3 Targz

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Posted 28 July 2020 - 03:39 AM

Where did you get it's orally active? In the phase 1 clinical trial they delivered the drug via subcutaneous injections.  

 

From the page linked above: "Athira Pharma was founded to commercialize the technology, and further development (of Dihexa) led to NDX-1017" 

 

My bad, but in their pipeline they do have a drug referred to as "2nd generation NDX" (which is likely very similar to NDX-1017) that's orally active. Not quite sure how I missed that...


Edited by Targz, 28 July 2020 - 03:41 AM.


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#4 William Sterog

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Posted 30 July 2020 - 09:55 AM

Very interesting.





Also tagged with one or more of these keywords: dihexa, analog, nootropic, clinical trial

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