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Cytotoxicity of Withaferin-A?

ashwagandha toxicity

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#1 adastra

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Posted 22 August 2020 - 08:57 PM

I came across a website that recommends that Ashwagandha should be sourced from the roots rather than from the leaves. One of their claims is that the concentration of Withaferin A in the roots is very low, and that this is a good thing, but it is high in leaves, and that's bad. I am not sure if this is just marketing copy or if there is something to this.
I checked the wikipedia page of Withaferin-A, and I cannot decide if its cytotoxicity only applies to cancerous cells or to a broader range:
Would anyone know if there is an issue here or if Ashwagandha sourced partly from the leaves is kosher?

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#2 Blueflash

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Posted 26 August 2020 - 12:45 AM

You might find the answer here, under "Things to note" https://examine.com/...ts/ashwagandha/  Basically they're saying at supplemented doses, it's safe. I tried the KSM-66, and it gave me excellent memory recall. I  supplement regular ashwaghanda, with small breaks every so often.

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#3 adastra

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Posted 26 August 2020 - 10:26 PM

Thanks for the link, Blueflash! Ideally I would like to get that root extract, but the regular KSM-66 is made with milk, used for the extraction process. They do say they have a non-dairy version, but I haven't seen it advertised anywhere, and I do wonder if it is equally as effective as the dairy version. I will ask around, but I am always open to suggestions. 

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