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COVID19 vaccine acceptance.

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Poll: COVID vaccine acceptance (22 member(s) have cast votes)

Would you be happy to receive a vaccine against SARS COV2 (COVID19)

  1. yes, quite happy (5 votes [22.73%])

    Percentage of vote: 22.73%

  2. not entirely, but would still take (3 votes [13.64%])

    Percentage of vote: 13.64%

  3. no, would not take (14 votes [63.64%])

    Percentage of vote: 63.64%

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#1 caliban

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Posted 23 September 2020 - 11:28 PM

Since the start of the COVID19 epidemic, research for a vaccine have proceeded at great speed. Now phase 3 trials are underway and it is hoped that vaccines may be available by the beginning of 2021.

For vaccines to succeed a very widespread uptake will be necessary. Given the unusual policy, scientific and health circumstances one might wonder about broad public acceptance.    


It is very early days.  As a vaccine comes closer more information will be available and attitudes may shift.

Consequently, you can change your vote after casting it. 


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#2 Dorian Grey

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Posted 24 September 2020 - 04:06 AM

I became a vaccine skeptic after I started taking the flu shot for a new job (healthcare) and wound up falling ill with astonishing swiftness 3 years running.  Falling ill shortly after getting the flu jab the most common reason cited for those refusing it now.  


Wolff, G., 2020. Influenza vaccination and respiratory virus interference among Department of Defense personnel during the 2017–2018 influenza season. Vaccine, 38(2), pp.350-354


“Receiving influenza vaccination may increase the risk of other respiratory viruses, a phenomenon known as virus interference.” 


“Examining non-influenza viruses specifically, the odds of both coronavirus and human metapneumovirus in vaccinated individuals were significantly higher when compared to unvaccinated individuals (OR = 1.36 and 1.51, respectively).” 


"This translates to a 36% higher risk of getting coronavirus"




The history of ominous adverse events with previous attempts at vaccines for original SARS doesn't exactly instill confidence.


Can We Beat SARS-CoV-2? Lessons From Other Coronaviruses  




Efforts to develop a SARS-CoV-1 vaccine have been thwarted in the past by antibody-dependent enhancement (ADE)-mediated vaccine-induced infection aggravation.17,18 In ferrets, rMVA-S vaccines were successful in inducing a rapid memory immune response, which is an essential feature of an effective prophylactic; but, when these ferrets were challenged with SARS-CoV-1, they developed enhanced liver damage.19,20 Likewise, in mice, SARS-CoV-1 vaccines utilizing either live SARS-CoV-1 or DNA-based S-protein were able to induce antibody formation and protection against SARS-CoV-1;21,22 however, challenged mice exhibited Th2-type immunopathology suggesting hypersensitivity to SARS-CoV-1 components.23 These results suggest that comprehensive evaluation of target SARS-CoV-2 signatures is required before vaccine trials ensue in humans, so as to prevent organ damage upon viral challenge. Specifically, scientists must identify different viral proteins or anti-Spike sera concentrations which would not induce ADE.




There is the potential for ADE (antibody dependent enhancement of disease), but the bigger problem is probably Th2 immunopathology.  The potential for antiphospholipid antibody syndrome is also a concern of mine (SARS-CoV-2 has a phospholipid membrane).  


The suppression of outpatient COVID therapeutics has shaken my faith in medical science to the core.




The new vaccines are going to require an EUA (Emergency Use Authorization) and in order to get this, there must be "No adequate, approved, and available alternative".  Any outpatient therapeutic would jeopardize the EUA for the vaccine, so these will not be tolerated.  They're herding the herd into the vaccine cattle chute, & I don't like it.   


I'll certainly reconsider getting the COVID jab next Fall if things go well with the launch, but I'll resist the urge to be at the front (or even middle) of the line for any "Warp Speed" SARS vaccine.  

Edited by Dorian Grey, 24 September 2020 - 04:56 AM.

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