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N-Acetyl Glucosamine-risks?

glucosamine chronic fatigue liver

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#1 experimenting

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Posted 04 October 2020 - 07:47 PM

Started taking this on the recommendation of a thread in this forum.

Has helped my constant pain, and ensuing horrible mood.

However I read that it may be bad on the liver/pancreas, may contribute to weight gain, etc. also, since having taking it, I weirdly feel like my ability to burn fat is worse.

I dealt with some liver issues a few years ago, and one thing I remember from that time is any fatty food would cause this weird warm/burning sensation on my left side, as if my body couldn’t break down fats effectively. I’m experiencing something like that now, could it be the NAG?

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#2 OlderThanThou2

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Posted 12 October 2020 - 02:41 PM

If I am not mistaken NAG increases hyaluronic acid:





Our data suggest that exogenous GlcN can increase HA production by synovium tissue and is more effective at lower concentrations than Gluc. This might indicate that GlcN exerts its potential analgesic properties through stimulation of synovial HA production.



The aim of this study was to evaluate the effect of liver diseases of different etiologies and clinical severity of liver cirrhosis on the serum level of hyaluronic acid. The results were compared with noninvasive markers of liver fibrosis: APRI, GAPRI, HAPRI, FIB-4 and Forn’s index. Serum samples were obtained from 20 healthy volunteers and patients suffering from alcoholic cirrhosis (AC)—57 patients, non-alcoholic cirrhosis (NAC)—30 and toxic hepatitis (HT)—22. Cirrhotic patients were classified according to Child–Pugh score. Hyaluronic acid concentration was measured by the immunochemical method. Non-patented indicators were calculated using special formulas. The mean serum hyaluronic acid concentration was significantly higher in AC, NAC and HT group in comparison with the control group. There were significant differences in the serum hyaluronic acid levels between liver diseases, and in AC they were significantly higher than those in NAC and HT group. The serum hyaluronic acid level differs significantly due to the severity of cirrhosis and was the highest in Child–Pugh class C. The sensitivity, specificity, accuracy, positive and negative predictive values and the area under the ROC curve for hyaluronic acid and all non-patented algorithms were high and similar to each other. We conclude that the concentration of hyaluronic acid changes in liver diseases and is affected by the severity of liver cirrhosis. Serum hyaluronic acid should be considered as a good marker for noninvasive diagnosis of liver damage, but the combination of markers is more useful.









Chronic liver diseases may cause inflammation and progressive scarring, over time leading to irreversible hepatic damage (cirrhosis). Hyaluronic acid (HA), an essential component of the extracellular matrix in virtually every tissue of the body, mostly synthesized by hepatic stellate cells and degraded by sinusoidal endothelial cells [1], has been found to correlate with the histological stages of liver fibrosis (F) in chronic liver diseases [2]. HA has shown very good diagnostic accuracy for the non-invasive assessment of fibrosis and cirrhosis [3,4]. The aim of this paper is a systematic literature review regarding HA for the assessment of liver fibrosis in chronic liver diseases: chronic viral C and B infections (CHC and CHB), non-alcoholic fatty liver disease (NAFLD), Human immunodeficiency virus/hepatitis C virus (HIV/HCV) coinfection, alcoholic liver disease (ALD), autoimmune disease and genetic disorders.



Also I've seen that HA plays a role in atherosclerosis. That's why I am wondering if it is good as a supplement.


My 2 cents.

Edited by OlderThanThou2, 12 October 2020 - 03:07 PM.

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#3 Hip

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Posted 12 October 2020 - 09:53 PM

"It turns out that glucosamine can cause weight gain or weight loss depending on your eating habits. In a high carb/low fat diet, it has the potential to cause weight gain. The exact type of diet I was eating was helping glucosamine turn me into a bloat monster. On the other side, if I was eating a high fat diet, it would help me lose weight.

It turns out that glucosamine can cause insulin resistance due to the ability of glucosamine to deplete ATP in the body (the body’s way of storing energy). Thus, the sensation of feeling exhausted all the time." Source: here.
"Our results show that GlcN increased body weight gain and reduced the insulin response for glucose maintenance when fed to normal CD [chow diet] mice, whereas it alleviated body weight gain and insulin resistance in HFD [high fat diet] mice."
"Oral glucosamine with routine dosage was safe in our non-diabetic patients with osteoarthritis and had no significant effect on glucose metabolism and insulin resistance." 

Edited by Hip, 12 October 2020 - 09:54 PM.

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