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Systemic approach to COVID management


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#1 9lives

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Posted 19 October 2020 - 03:27 AM

I'd like to share my perspective on COVID-19 management after spending countless hours researching. Part of the problem is many are looking for that silver bullet. But a number of leading treatments have failed in providing the desired results [1], which leads me to believe much of the recovery comes down to our own immune function and reducing the inflammatory immune response which follows. Also vaccines ... several are on pause as vaccine researchers investigate adverse reactions observed in their clinical trials. Evaluating individual treatments is helpful, however important to note that COVID-19 is a complex disease that must be met with an equally sophisticated treatment plan. Such a plan needs to be laid out with absolute clarity among the science and medical communities. I feel the optimal situation is treating in the most proactive, natural way possible while aiming to minimize side effects from the virus, the treatments, and avoiding the long hauler symptoms which may arise. The situation gets a lot more dire in the moderate to severe cases, so researching treatments with a focus on those stages is not where we as biohackers want to invest as much of our time if we're looking to beat this virus in a meaningful way. Surely, if you're in that position, get to a hospital right away!


One of the most comprehensive treatment plans out there is MATH+. [2] It promotes a phased approach which is important, and so I take some elements from it. There are also some points that are worth adding, and this is what I follow for myself (disclaimer: educational purposes only).

- Minimize exposure
- Address nutritional deficiencies with sensitivity to Covid-19; immune support supplements


==> Test for Covid if experiencing symptoms, but only as a loose gauge due to limited accuracy


- Increase T cells to prevent CD8 exhaustion, not NK which is assoc. w/ cytokine storm [3]
- Antivirals especially with specificity to CoV2 and CoV that target spike protein, TMPRSS2, and furin; other protein targets may be effective also. This step is critical in reducing viral load and significant immune response viral debris. Reduce viral load both systemically and in upper respiratory.

  * Influenza shares the characteristic of being an enveloped RNA virus, and some treatments may have relevance. Must take it on a case by case basis.


==> Test for Covid, but only as a loose gauge due to limited accuracy

- Stop immune enhancing treatments
- Promote Treg function
- Aggressively inhibit bradykinin to prevent Bradykinin Storm. [4]
- Promote ACE expression to help regulate Bradykinin
- Reduce inflammation (with anti-oxidants, anti-inflammatories, etc.)


I have a very detailed regimen around the above, and I can get into it more if folks are interested. Fortunately I haven't had to put it to the test yet. But I feel it includes all the latest science and leaves less gaps.

[1] https://www.who.int/...d-19-treatments

[2] https://www.evms.edu...19_Protocol.pdf

[3] https://science.scie...science.abc8511

[4] https://elifescience.../articles/59177

Edited by 9lives, 19 October 2020 - 04:14 AM.

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#2 Dorian Grey

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Posted 19 October 2020 - 05:30 AM

Great Post 9lives.  I've been thinking we need a thread to publish our (semi) finalized SARS-CoV-2 thesis & protocols.  I've discussed potential therapies with my doctor, & he said that other than checking Vitamin-D levels, he has absolutely nothing to offer unless & until I am hospitalized, so I have focused on home based therapeutics.  I've always been wary of kitchen sink (doing too much) when it comes to disease intervention, so I've limited my protocol to ameliorating the critical aspects that occur early in the disease process.  


For Immune Support, other than Vitamin-D & Zinc with Ionophore, I like what I've read about Lactoferrin regarding stimulation of T-Cell activity.  




Other than Zinc with Ionophore, there's not a lot of over the counter outpatient therapeutics regarding viral replication inhibitors, but I find the lipid soluble alkalizing agents (caffeine, nicotine (gum/patch), theobromine and quinine) intriguing, due to the theoretical benefit of HCQ, as well as the "smokers paradox" (protective effect of nicotine).  This may be a forlorn hope, but with reasonable safety profiles, something I incorporate into both prophylaxis and potential acute therapeutic.  Coronavirus is a fast replicator, so if you don't do something prophylactically or within 48 hours of symptom onset, delayed attempts at inhibiting replication may be futile.  


The only Bradykinin Inhibitor I've found for home use is Bromelain, so I have this on hand for early use at home.  Don't know how effective this might be against a COVID bradykinin storm, but better to light a candle than curse the darkness.  


Anticoagulation is a primary focus for me, as once your lungs get clotted up you've already hit the iceberg from what I've seen.  I'll be attacking this on multiple fronts with NAC, Vitamin-E, low dose aspirin, and quinine, all of which work from different angles at preventing clotting disorders.  


Immune modulation to inhibit cytokine storm is another primary focus, with limited options available for home use.  I've read Naproxen was being looked at last Spring, but haven't followed the studies.  My forlorn hope at immune modulation rests primarily in Quinine (cinchona bark).  While the chloroquine meds haven't performed impressively as salvage meds in hospitalized patients, or even infection prophylaxis, I find their immune modulating properties remarkable. 


The impressive Dexamethasone benefit that surfaced not too long ago has put steroids in the spotlight, but timing is everything when it comes to steroid intervention during infection.  A little too early or late, & you've missed a very narrow sweet spot.  Don't try this at home! 


Dr Syed Mobeen stated in one of his lectures that the chloroquine meds were the only immune modulators that have never been known to significantly predispose secondary infections or potentiate existing infections, which is why they are still popular today for treating autoimmune conditions.  To me, this would seem to be the ideal outpatient immune modulator for early stage COVID.  Quinine also lowers blood glucose as well as inhibiting clot formation.  Cinchona bark is available from amazon, & quinine content & dosing can be found online.  Better to light a candle than do nothing and call 911 if you start turning blue?  I think so!  


Lastly, I want an antifibrotic to help heal tissues damaged by the disease.  I'm not particularly afraid of death, but I don't want to live out the remainder of my life as a pulmonary or cardiac cripple.  PPC (polyenylphosphatidylcholine) is the best antifibrotic I have found:




Vitamin-E also has anti-scarring potential, & I'll be on this during recovery too.  


For references and details, dive into our Supplements & Therapies thread:  https://www.longecit...ents-therapies/


Hours of interesting reading!  

Edited by Dorian Grey, 19 October 2020 - 06:12 AM.

#3 9lives

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Posted 19 October 2020 - 07:04 AM

@Dorian, good stuff! A lot of what you've mentioned resonates with me. In the end our protocols may be slightly different, but we're thinking along the same lines and I'm all for coming up with a universal protocol.


Lactoferrin is on my list for Phase 1, as I don't want to amp my immune system for too long. I have more studies on it you'd probably like. I find the smoker's paradox interesting. I read there's a modest increase in risk, but not as much as expected (possibly tied to nicotine as you suggest). Some of those others I'll have to look into.

So if we may structure our discussion in parts, can we start with the preventatives? i.e. addressing nutritional deficiencies + immune support supplements. I already have a base regimen that includes a multi-vitamin and other supplements, so what I have below is more targeted or relevant to the discussion.

Here's how my list compares, recognizing that people may require different dosing:
- Vitamin C, 1g (liposomal)
- B complex
- Quercetin Phytosome, 250mg (this is my zinc ionophore, as I mostly found negative studies for HCQ; Dr. Been has recently acknowledged this finding in the WHO recent study I referenced in above post)
- Luteolin
- Potassium (150mg)
- Melatonin
- Vitamin D (blood serum levels at 45 - 60 ng/mL)
- Vitamin E tocotrienols & tocopherols
- Zinc acetate, 20mg (balanced with Copper)
- NAC, 600mg (preventive dose)
- Selenium
- Linoleic acid (small amount of dietary LA in proper ratio to omega-3)
- Thyroid hormone support (if needed)
- Iron (micro-dosed since men's RDA is lower)
- Magnesium


REFS: (you'll notice 1 study covers plenty, however many studies out there supporting these)
Zinc: https://www.foundmyf...474?t=01h01m40s
Quercetin: https://link.springe...020-00250-4.pdf
Vitamin B: https://www.frontier...2020.00476/full
Vitamin D: https://elifescience...icles/59177.pdf
Vitamin D: https://www.frontier...2020.00476/full
Vitamin E: https://www.frontier...2020.00476/full
NAC: https://pubs.acs.org...nfecdis.0c00288
Selenium: https://www.mdpi.com...3/11/9/2101/htm
Zinc: https://www.frontier...2020.00476/full
Lueolin: https://link.springe...020-00250-4.pdf
Lueolin: https://www.research...cle/rs-35368/v1
Lueolin: https://selfhacked.c...eolin-benefits/
Lueolin: https://www.ncbi.nlm...les/PMC5801364/
Lueolin: https://www.ncbi.nlm...cles/PMC521800/
Lueolin: https://journals.plo...l.ppat.1008887"
Vitamin C: https://www.jmptonli...0005-9/fulltext
Vitamin C: https://www.frontier...2020.00476/full
Magnesium: https://www.frontier...2020.00476/full
Iodine: https://www.frontier...2020.00476/full
Linoleic acid: https://science.scie...ce.abd3255.full


[EDIT] A supporting study from other thread ... "six vitamins (D, A, C, Folate, B6, B12) and four minerals (zinc, iron, copper and selenium) to be essential for the normal functioning of the immune system."


Edited by 9lives, 19 October 2020 - 07:26 AM.

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#4 Mind

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Posted 19 October 2020 - 05:16 PM

Thanks for the insights and data 9lives. Like many on this forum, and thousands of doctors around the world, we wonder why this information is not being distributed more widely to the general public.

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#5 9lives

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Posted 19 October 2020 - 11:17 PM

@ Mind - Thanks! And yes, that's very true. I will say though that while there are still those who are seeking to profit from this pandemic and suppress information not supported by big pharma, scientific data on alternative treatments has been more difficult to obtain in the past. The number of clinical trials we have running which promote natural treatments is unbelievable, and it's so great that the scientific journals have made Covid related studies open access. Through this push to solve the pandemic ... scientists have further clarified some key biological mechanisms which were previously not well understood and they've compiled data on health outcomes for alternative therapies. Plus, we can ride off key learnings from pharmacokinetics and instead utilize natural compounds with similar mechanisms of action. Another benefit is I see this all translating into better treatments for other enveloped RNA viruses like the flu.Studies are literally being produced so fast, that pre-prints are more accepted if from a well-designed study, and something reported a month ago might be old science.


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