4 replies to this topic

[maestro949]

Wiki

EC Repository - Website w/Links, etc

Just ordered this book. I'll post a review in the book section once I've digeested a good portion of it.

Evolutionary Computation in Bioinformatics - Link to TOC

Evolutionary Computation in Bioinformatics - Amazon Link


Genetic Algorithms in Search, Optimization, and Machine Learning - Amazon Link

MIT Press Journals - Evolutionary Computation

Edited by maestro949, 24 June 2006 - 01:51 PM.

[maestro949]

Joao Pedro de Magalhaes' Thesis on Modeling Aging

Chapters 9-11 are of particular interest regarding models of aging (9&10) and bioinformatics (11).

Chapter 9: Models of human ageing
* 9.1. Lessons from the evolution of ageing
* 9.2. Animal models
* 9.3. Human models
* 9.3.1. Centenarians
* 9.3.2. Werner's syndrome
* 9.4. Cellular models
* 9.4.1. Senescence, RS, and SIPS
* 9.4.2. Comparative biology
* 9.5. Computer models
* 9.6. Developing anti-ageing therapies
* 9.6.1. Telomerase alters the normal cellular functions
Chapter 10: DNA damage, ageing, and SIPS 107
* 10.1. Critical telomere shortening is not necessary for SIPS
* 10.2. DNA damage induces cellular senescence through complementary pathways
* 10.3. RS versus SIPS
* 10.4. DNA metabolism and ageing
Chapter 11: How bioinformatics can help reverse engineer human aging 116
* 11.1. Introduction
* 11.2. Data-mining methods
* 11.2.1. Comparative genomics of ageing
* 11.2.2. Transcriptional regulation of ageing
* 11.2.3. DNA microarrays
* 11.3. Modelling human ageing
* 11.3.1. System structure and identification
* 11.3.2. System-level perturbations in model organisms
* 11.3.3. Reconstructing the genetic network of human aging
* 11.4. Conclusion: is it possible to reverse engineer human aging?

Edited by maestro949, 24 June 2006 - 01:49 PM.

[emerson]

The only one I've given much more than a quick glance at so far is Magalhaes' PDF, but it's enough to be certain I've got a good amount of reading in my future. The Evolutionary Computation Journal link though is like dangling candy in front of a baby. I'm strapped down by lack of funds, but those articles are glimmering with the sugarlike sheen of esoteric code. And the fun-size snicker of journals, the ever wonderful abstract, is making an addict of me already.

Many thanks for all the links, and Magalhaes' thesis in particular!

[maestro949]

No problem.

The thesis is a good read. The All Roads Lead to Rome section was interesting. I flagged it to come back and study the pathways metioned as some recent positive developments have come out on the progeria front which also mentioned some of the same pathways. One of the issues with researching this stuff is that it's advancing so rapidly, something written a year or two ago has likely progressed significantly. Not easy when you're trying to learn the fundamentals and keep up the current science and trends.

Esoteric indeed. In the tools thread I posted some links to a few java packages which were fun to peruse. Other than prototyping some hello world apps I have no intention of slogging much code though.

[emerson]

One of the issues with researching this stuff is that it's advancing so rapidly, something written a year or two ago has likely progressed significantly.  Not easy when you're trying to learn the fundamentals and keep up the current science and trends.

Tell me about it. My last major dive into the subject is a couple years old at this point. It's been a bit of a rude awakening to see just how far into orbit I've been thrown by my procrastination. The fact that it's a multidisciplinary subject also throws a few extra buckets of effort on top of keeping up with the flow. Still, despite any personal annoyances that might come, in the long run I'm thrilled to see things advancing so fast. It may create difficulties on my own individual level, but I'd rather find myself in a position of grabbing some extra study time than in a state where I needed a big medical advance that had been stalled due to lack of tools.