2 replies to this topic

[MikeDC]

https://www.cell.com...30?showall=true
Highlights

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SARM1 is activated by an increase in the ratio of NMN to NAD +
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NMN and NAD + compete for binding to the auto-inhibitory ARM domain of SARM1
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NMN binding influences the structure of SARM1
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NMN binding is required for injury-induced SARM1 activation and axon destruction

[Oakman]

Can you explain, in lay terms, what this means?

[MikeDC]

Can you explain, in lay terms, what this means?

NMN compete with NAD+ to bind with SARM1. When NMN level is high, NMN binding to SARM1 is increased and causes SARM1 activation. SARM1 activation depletes NAD+ and causes axon degeneration.