So as we all know CD38 is a major NAD consumer and apigenin has been shown to suppress CD38 levels. The problem is that apigenin has serious bioavailability issues. And once you isolate it and put it into a supplement its even less bioavailable since its no longer bound to a sugar molecule/glycoside
https://www.hindawi....i/2019/7010467/
Those glycoside conjugates, primarily as apigenin-7-O-glucoside, and acylated derivatives are more water soluble than apigenin [10] and their structures have a major impact on their absorption and bioavailability, with the best bioavailability occurring when apigenin is bound to β-glycosides [9].
the most bioavailable form of apigenin is going to be the form found in its natural setting - in a strawberry or other plant.
So why not genetically engineer strawberries to express extremely high levels of apigenin? 5 or 10 or 50 times normal levels. This strawberry would then have anti aging properties as it would deliver extremely highly bioavailable apigenin to the body.
same with apples, genetically engineer them to express extremely high levels of quercetin. Now you have an apple that not only suppresses CS38 but also helps to clear senescent cells.
Barring this fantasy from happening, maybe there is a way to take pure apigenin/quercetin/fisetin and create a chemical reaction at home that binds it to a sugar molecule thus increasing its bioavailability.