3 replies to this topic

[Phoebus]

So as we all know CD38 is a major NAD consumer and apigenin has been shown to suppress CD38 levels. The problem is that apigenin has serious bioavailability issues. And once you isolate it and put it into a supplement its even less bioavailable since its no longer bound to a sugar molecule/glycoside

 

https://www.hindawi....i/2019/7010467/

 

 

 

Those glycoside conjugates, primarily as apigenin-7-O-glucoside, and acylated derivatives are more water soluble than apigenin [10] and their structures have a major impact on their absorption and bioavailability, with the best bioavailability occurring when apigenin is bound to β-glycosides [9].

 

the most bioavailable form of apigenin is going to be the form found in its natural setting - in a strawberry or other plant. 

 

So why not genetically engineer strawberries to express extremely high levels of apigenin? 5 or 10 or 50  times normal levels. This strawberry would then have anti aging properties as it would deliver extremely highly bioavailable apigenin to the body. 

 

same with apples, genetically engineer them to express extremely high levels of quercetin. Now you have an apple that not only suppresses CS38 but also helps to clear senescent cells. 

 

Barring this fantasy from happening, maybe there is a way to take pure apigenin/quercetin/fisetin and create a chemical reaction at home that binds it to a sugar molecule thus increasing its bioavailability. 

[pamojja]

the most bioavailable form of apigenin is going to be the form found in its natural setting..

 

Barring this fantasy from happening,..

 

Why so complicated? https://www.ncbi.nlm...les/PMC5791748/

 

Dried parsley has been reported to have the maximum quantity of apigenin, at 45,035 μg/g. Additional sources of apigenin are dried flower of chamomile, containing 3,000 to 5,000 μg/g; celery seeds, containing 786.5 μg/g; and vine spinach and Chinese celery, containing 622 μg/g and 240.2 μg/g [16].

 

Nothing easier than to put 1 or 2g of dried parsley into your daily green smoothie, and receive either 45 or 90 mg of Apigenin. And in this case even more bioavailable than from supplements.

 

https://microbiomepr...Details?fid=789

 

 

Caper, canned

Quercetin

172.55 mg/d

 

And add a couple of canned capers to your meal.

 

Only with Fisetin its harder to get supplemental amounts. The highest content in Strawberries is allegdedly only 0.16 mg/g - https://en.m.wikiped...rg/wiki/Fisetin - Maybe freeze-dried powders, which I saw made from 10 times the strawberries, in a red smoothie?

 

 

 

[Phoebus]

Excellent point, unfortunately I am allergic to parsley 

 

also the fundamental point still stands. Genetically modify produce to express very high levels of various anti aging compounds sounds like a really good idea to me. 

[Harkijn]

Then again  (as per CD38 threads) CD38 is not always a negative player . Some CD38 inhibition seems ok but CD38 restriction need not be a positive thing?