I don't think I would do senolytic dosing of fisetin (or any senolytic) on a daily basis for any length of time.
It doesn't seem to be needed. As a senolytic, it seems to be effective in a 2-3 day regimen (F and D+Q). Also, you are altering a number of key enzymes and protein synthesis chains. Chronic (i.e. daily) use could have unwanted effects outside its senolytic activity. Finally the senolytic effect seems to be dose dependent, i.e. low doses don't seem to exert much senolytic effect. The Mayo clinic hit on 20mg/kg for safe use in frail 70+ women. Mouse studies have gone as high as 2000mg/kg acute dose with no adverse effects. Finally, you are killing off cells. It is probably a good idea to allow time for removal and healing.
Just an aside... Berberine looks to be a mTOR1 inhibitor like rapamycin only without all the nasty side effects (and they potentiate each other).