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Coronavirus - Covid-19 - Vaccine and Aging conjunctions


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#1 qge

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Posted 17 October 2021 - 08:29 PM

Here are some studies linking Covid and aging .
Epigenomics in COVID-19; the link between DNA methylation, histone modifications and SARS-CoV-2 infection





Evidence for Biological Age Acceleration and Telomere Shortening in COVID-19 Survivor



Virus-induced senescence is driver and therapeutic target in COVID-19

Methylation Effects of COV-19 Infection and Vaccinations


Increased mTOR signaling, impaired autophagic flux and cell-to-cell viral transmission are hallmarks of SARS-CoV-2 infection


Preclinical research shows that COVID-19 infection may dysregulate NAD+ synthesis


Mitochondria and microbiota dysfunction in COVID-19 pathogenesis


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#2 Dorian Grey

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Posted 18 October 2021 - 05:26 AM

Thanks for this qge.  Scary stuff!  


I was intrigued by Dr Seheult (MedCram) when he spoke of COVID morbidity as a runaway inflammation syndrome early on.  Inflammation is aging / aging is inflammation.  


My pre-COVID interest was "Ferrotoxic Disease", and the role of oxidative stress from iron in aging & disease.  There is a crossover with COVID in that the micro-clotting may be releasing a lot of free/labile iron as the macrophages digest the clots.  Hydroxyl radicals one of the most destructive forces in human physiology.  Long COVID may be a mitochondrial damage issue, as iron dysregulation is particularly damaging to mitochondrial membranes.  


Interesting too, males tend to accumulate iron as they age, & elderly males are worst hit by COVID morbidity.  Children & menstruating females are typically low on iron, and fare much better with COVID morbidity.  


Macrophages typically pass off excess iron to ferroportin, but during infection and inflammation, hepciden (iron transport regulatory hormone) spikes sky high, which disables ferroportin.  When macrophages can't offload iron, they undergo "ferroptosis", which may spill reactive iron locally into tissue & blood.  Don't know of anything that will age a body more than a massive systemic spill of reactive free/labile iron.  We already know high spikes of ferritin are associated with increased morbidity.  


Interesting curcumin & quercetin (both potent iron chelators) are often mentioned as ameliorating COVID morbidity.  IP6 (inositol hexaphosphate / phytic acid) may be helpful during the inflammatory phase.  


Of course, if you can avoid micro-clot formation in the first place, you'll likely head off a substantial amount of the inflammation cascade.  Have noticed the boffins are starting to notice the importance of full dose anticoagulant therapeutics.  


Thank you for this contribution!  It's an interesting angle that should be explored further.  

Edited by Dorian Grey, 18 October 2021 - 05:43 AM.

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#3 qge

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Posted 13 November 2021 - 09:45 PM

Hi, finally I got infected too.
I was not vaccinated given my age 46.
I had a fever one night and the next day.
I have taken the following supplements since the first day of fever for 15 days:

Vitamin C (ascorbic Acid ) + Quercetin 
Vitamin D 6000 UI
Green Tea 
Nicotinammide Riboside + Resveratrol
VSL3 (Probiotic)
Vitamin C (Ascorbil Palmitate ) 
Boswellia (5lox-inibitor)
Zinc 50 Mg
From the third day I have had no more symptoms and today I am very well.
All supplement are Life Extension dosing x 1 Pils
I hope my experience can be usefull for someone

Edited by qge, 13 November 2021 - 10:06 PM.

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#4 Hip

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Posted 14 November 2021 - 03:05 AM

Well that's one more virus you have in your body, qge, so nothing much to worry about, considering adults already have dozens of different nasty viral species in their bodies, which will remain in their tissues for their entire life, subtly screwing up the functioning of the body until eventually the virus triggers a nasty chronic disease. Not to mention the dozens of different species of bacteria living in the body, living as impossible to eradicate biofilms or L-forms, which also have massive disease-causing potential.


Almost every chronic disease has been linked to infectious pathogens


Most people in the anti-aging community do not realize that the most likely cause of reduced healthspan and premature death is the many infectious pathogens which live in the human body, and mess up normal bodily function, especially immune function (pathogens purposely throw spanners in the workings of the immune system, so that they avoid being killed by the immune response).

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