3 replies to this topic

[Ovidus]

We know the relationship between inflammation and aging of course. In the below video, the scientist (David Furman) goes into detail about which specific subtypes of inflammation are most important for aging 

 

 

and identifies CXCL-9 as a crucial target. He says that by blocking the expression of CXCL-9 they were able to restore a youthful phenotype.

Unfortuanately a quick search does not bring up an easy and convenient way to block it nor was I able to find the study he refers to in the video. 

[fauxstradamus]

I wonder if plasmapheresis would lower it . . . more than just transiently (ie., for at least a few months)?

 

Or better yet would cause a lasting reset to a new, lower level.

 

Do you know if there are readily available, well-validated tests for CXCL-9 that one's doctor could order through a university health system diagnostic lab, for example or Mayo?

 

I've had plasmapheresis and I will probably have it again.   I did an extensive panel of bloodwork before and after the procedures, but I'm pretty sure CXCL-9 was not included.   It would be very interesting to test CXCL-9 level before and after (say a month after) a series of plasmapheresis procedures.

 

Finally, I wonder if the Conboys tested for this in their post-parabiosis, mouse experiments involving plasma exchange with albumin?  Remember they saw profound rejuvenation effects by simply removing "bad" old blood components (as opposed to adding beneficial young blood or young blood components).  Maybe CXCL-9 reduction in part explains the rejuvenation effects they saw when they simply removed plasma and replaced it with saline and albumin?

[fauxstradamus]

. . . or maybe Sildenafil (Viagra)??

 

https://www.ncbi.nlm...les/PMC8229934/

 

Sildenafil Counteracts the In Vitro Activation of CXCL-9, CXCL-10 and CXCL-11/CXCR3 Axis Induced by Reactive Oxygen Species in Scleroderma Fibroblasts (Biology (Basel) 2021)

[sensei]

MTORC1 activates CXCL-9.

https://www.ncbi.nlm...les/PMC5171795/

One can propose MTORC1 inhibition would inhibit CXCL-9 release.

Rapamycin, Prolonged Fasting, and some polyphenols like oleocanthal, fisetin, and genistein inhibit MTORC1.