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Transcription/Growth Factor and their respected agonists.

brain growth

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#1 Automail

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Posted 26 December 2021 - 12:56 AM

ADNF: activity-dependent neurotrophic factor

ADNF-9, NAP, AL-309, Colivelin, Davunetide

BDNF: Brain-derived neurotrophic factor


BMP7: Bone Morphogenetic Protein 7)

rhBMP-7, LPP, Hwanggeumchal sorghum extract

CDNF: Cerebral Dopamine Neurotropic Factor


CNTF: Ciliary neurotrophic factor


CSF: (Colony-stimulating factor)


EGF: Epidermal growth factor

Resveratrol, Estrogen, Brimonidine, fluoxetine, Bromocriptine? Progesterone, dexmedetomidine

FGF-1?, 2, 7, 8, 9, 10, 17, 22 (FGFR2) Fibroblast growth factors

nicotine, Gluco- and mineralocorticoid receptors agonists, Trafermin, Taurine

GDNF: Glial cell line-derived neurotrophic factor


HB-EGF? Heparin-binding EGF-like growth factor?

All-trans RA, AM251, dexmedetomidine, kainate and N-methyl-D-aspartate, rosiglitazone

HGH: human growth hormone


HGF: Hepatocyte growth factor

Dihexa, glutamine, proline, as well as leucine, Withaferin A, K1K1,

HH: Hedgehog

Purmorphamine, 9-me-BC, SAG, Neurodazine, leiosamines

IGF-1: Insulin-like growth factor 1

Arginine and ornithine, FGL, Mecasermin rinfabate

MANF: Mesencephalic astrocyte-derived neurotrophic factor



diarylpropionitrile, retinoic acid, Rebamipide

NGF: Nerve growth factor


NT3: Neurotrophin-3

histamine agonists, Neotrofin, cannabinoids, LM22B-10, , Ziziphus Jujuba

PDGF: Platelet-derived growth factor

LP 12, PEA with luteolin, Chitosan, GW0742

PGF/PlGF: placental growth factor

https://journals.plo...al.pone.0244684 low-intensity pulsed ultrasound, 15-HETE

SCF: Stem cell factor

NSI-189, Leuprolide? adenosine A3 agonists, Ancestim

VEGF: vascular endothelial growth factor

VIP, Nicotine, Thiamin, citicoline, phenibut, Astragalus, Lithium, Semax

VGF: VGF nerve growth factor inducible

TLQP-21, Rapastinel, PF-4778574, Crocin, Curcumin? Imipramine,

WNT: Wingless type

PCB-95, ambroxol, Curcumin nanoparticles, lithium, Ajuga turkestanica(?), resveratrol, Glucosamine


Edited by Automail, 26 December 2021 - 12:57 AM.

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#2 Mr Matsubayashi

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Posted 27 December 2021 - 11:36 AM

Intreresting, my reply self combusted? 
Anyway, in short Icariin for IGF-1 and Centella asiatica ethanol extract for VEGF are two of my favs. 

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#3 Mr Matsubayashi

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Posted 28 December 2021 - 01:40 AM

Another fav is Lutein, zeaxanthin


Between Icariin, Lutein, Centella Asiatica, 7,8, DHF and Polygala I feel all the bases are covered. All of these are easily attainable, safe, cheap/dose, bioavailable (sublingual in the case of DHF, Polygala, enteric coated or sublingual for Centella Asiatica). I find Luteolin, DHF stimulating. Icariin, Centella, Polygala sedating so I take them in the evening. 


Something I would like to do more homework on is food for growing/multiplying nerve cells. I think the happy stack is a good starting place, combined with glucose or even better short chain fatty acids. Short chain fatty acids are amazing especially when they originate from your gut nomming on resistant starches. I like taking inulin in the evening, it's sedating and great for sleep. 

Edited by Mr Matsubayashi, 28 December 2021 - 02:10 AM.

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#4 Mr Matsubayashi

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Posted 28 December 2021 - 01:52 AM

It's amazing how many compounds that promote growth factors are found naturally in plant foods. Eating plant based might be the first thing someone should do when optimising their brain hardware. And then not forgetting that amazing hardware is nothing without software to take advantage of it. Go socialise, play a sport, read a book, learn something new, in everything you do practise consciously. 

Edited by Mr Matsubayashi, 28 December 2021 - 01:55 AM.

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