• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
* * * * * 1 votes

Supplements that make time go slow?

supplements

  • Please log in to reply
8 replies to this topic

#1 bce

  • Guest
  • 12 posts
  • 2
  • Location:Noway

Posted 09 May 2022 - 12:36 PM


Hi!!

 

I have this problem that time seems to be going really fast. I wake up, its lunch and before i know it its time to go to bed. 

in all seriousness i think its due to some underlying depression but i also think age has to do with it. When i was young, or as a kid, an hour could feel like a really long time. Now its more or less a blink of an eye.

 

Recently ive been trying beta-alanin, a few grams before bed. And all of a sudden time is going slower. Why is that? Do you have any experience with supplements that has made your days seem longer?

 

 

 

 



#2 medievil

  • Guest Guest
  • 3,758 posts
  • 20
  • Location:Belguim

Posted 29 May 2022 - 12:27 PM

Madonna in my experience makes time go slower it is a serotonin releasing agent and it is a promising treatment for depression on paper
I meant mdai must have been autocorrect

sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#3 Turnbuckle

  • Location:USA
  • NO

Posted 29 May 2022 - 07:13 PM

And interesting observation. The perception of time seems to be tied to dopamine neurons in a particular brain region --

 

Dopamine neurons in a brain region known as the substantia nigra pars compacta can alter the perception of time, according to new research published in Science in December. Stimulating or inhibiting these cells makes mice behave as if time is moving faster or slower, the researchers found. More specifically, boosting dopamine activity slows down the animals’ internal clock, leading them to underestimate time intervals.

https://www.simonsfo...eption-of-time/

 

 

Parkinson's disease destroys dopamine neurons, and that alters the perception of time--

 

The team demonstrated that Parkinson’s disease significantly diminishes the time perception ability of patients — whether newly diagnosed with few symptoms or far into the disease progression, and whether or not they were using medication or brain stimulation therapy. 

https://engineering....time-perception

 

 

Carnosine is a dipeptide of beta-alanine and histidine, where the availability of beta-alanine is the limiting factor. Both carnosine and beta-alanine have been shown to increase dopamine in mice in the region involved with time perception --

 

In a genetic mouse model of PD characterized by overexpression of α-synuclein, two months of intranasal carnosine intake increased gene transcription of mitochondrial complexes I, IV, and V, protein levels of mitochondrial complex V, and mitochondrial maximal and complex IV-driven respiration [118], which counteracts the well-recognized mitochondrial dysfunction in PD [119]. Further extending this evidence, the carnosine precursor β-alanine was shown to improve motor symptoms of PD and increase extracellular levels of GABA [120] as well as dopamine in substantia nigra [121].

https://www.ncbi.nlm...les/PMC6627134/

 

 


Edited by Turnbuckle, 29 May 2022 - 07:17 PM.

  • Informative x 1
  • Cheerful x 1

#4 bce

  • Topic Starter
  • Guest
  • 12 posts
  • 2
  • Location:Noway

Posted 10 June 2022 - 01:05 PM

And interesting observation. The perception of time seems to be tied to dopamine neurons in a particular brain region --

 

 

Parkinson's disease destroys dopamine neurons, and that alters the perception of time--

 

 

Carnosine is a dipeptide of beta-alanine and histidine, where the availability of beta-alanine is the limiting factor. Both carnosine and beta-alanine have been shown to increase dopamine in mice in the region involved with time perception --

 

Wow, cool! Substantia nigra... Will try carnosine supplements to see if i can get any similar results. 

 

Are there any other common ways of increasing dopamine in the substantia nigra region? Im not getting any noticeable time slowing effects from dopamine agonists like tyrosine or methylphenidate.

Parkingssons medications might work? but would be hard for me to get a hold of, like Pramipexole...

 

Thanks!! :)


Edited by bce, 10 June 2022 - 01:13 PM.


#5 Turnbuckle

  • Location:USA
  • NO

Posted 10 June 2022 - 02:05 PM

I've notice a slowing of time with beta-alanine, but nothing substantial with carnosine, nor with L-dopa.



#6 kurdishfella

  • Guest
  • 2,397 posts
  • -69
  • Location:russia
  • NO

Posted 10 June 2022 - 06:56 PM

Anything that makes your brain work faster and better will make time seem slower. So if you increase BDNF,NGF etc your brain will take in more info and be more aware and thus you will feel like time goes very slow.


  • Good Point x 1

#7 bce

  • Topic Starter
  • Guest
  • 12 posts
  • 2
  • Location:Noway

Posted 10 June 2022 - 11:18 PM

Anything that makes your brain work faster and better will make time seem slower. So if you increase BDNF,NGF etc your brain will take in more info and be more aware and thus you will feel like time goes very slow.

 

Interesting! Ive actually been working on increasing BDNF for quite some time through different stuff like Niacin, Lithium Orotate, Quercetin, Curcumin, Bacopa and on and off on Rhodiola but nothing to me is as significant as Beta-alanine, im really leaning more towards that "agonising substantia nigra theory"... Just need to find more things that focuses on that region of the brain. :)


Edited by bce, 10 June 2022 - 11:20 PM.


#8 Turnbuckle

  • Location:USA
  • NO

Posted 10 June 2022 - 11:49 PM

Interesting! Ive actually been working on increasing BDNF for quite some time through different stuff like Niacin, Lithium Orotate, Quercetin, Curcumin, Bacopa and on and off on Rhodiola but nothing to me is as significant as Beta-alanine, im really leaning more towards that "agonising substantia nigra theory"... Just need to find more things that focuses on that region of the brain. :)

 

 

Oliver Sacks' Awakenings patients supposedly suffered damage to the substantia nigra. They seemed to stop for outside observers, but from inside, time must have rushed by.


Edited by Turnbuckle, 10 June 2022 - 11:50 PM.

  • WellResearched x 1

sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#9 irony

  • Guest
  • 55 posts
  • 3
  • Location:California

Posted 19 June 2022 - 01:46 AM

not a supp, but the TCA antidepressant despiramine notably makes time feel like it has slowed down for me.


  • like x 1





Also tagged with one or more of these keywords: supplements

0 user(s) are reading this topic

0 members, 0 guests, 0 anonymous users