7 replies to this topic

[Michael Lustgarten]

https://www.youtube....h?v=BwJmuQ7ubkM

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[Michael Lustgarten]

Epigenetic Test #4: What's My Biological Age?

 

 

 

[Mind]

In addition to asking the question of "how can a person reduce their Horvath epigenetic age?", we should also be asking "is the Horvath clock a true measure of biological age?" If every other test (including functional aging tests) show that your biological age is less than your chronological age, then maybe there is a problem with the Horvath clock or its methods.

[Michael Lustgarten]

In terms of its correlation with chronological age, Horvath's has the best correlation. But, it's not consistently associated with all-cause mortality risk, especially in comparison to other clocks like PhenoAge, GrimAge, and DunedinPACE.

[smithx]

In terms of its correlation with chronological age, Horvath's has the best correlation. But, it's not consistently associated with all-cause mortality risk, especially in comparison to other clocks like PhenoAge, GrimAge, and DunedinPACE.

 

What do you make of results like the ones I got from Tally Health's new epigenetic age panel, that are 23 years older than my PhenoAge and 8 years older than my chronological age?

 

I'm not sure how useful any of these tests can be if they have a 40% variance with respect to chronological age.

[Michael Lustgarten]

What do you make of results like the ones I got from Tally Health's new epigenetic age panel, that are 23 years older than my PhenoAge and 8 years older than my chronological age?

 

I'm not sure how useful any of these tests can be if they have a 40% variance with respect to chronological age.

 

In contrast with the gold standard clocks (Horvath, Hannum, DunedinPACE, PhenoAge, GrimAge), Tally Health's epigenetic clock has not been evaluated for its chronological age in a large cohort (> 10,000 people), or its association with all-cause mortality risk. So I'd say buyer beware until then, and I'd like to see how it compares head-to-head with the other clocks.

Edited by Michael Lustgarten, 13 March 2023 - 11:45 AM.

[smithx]

Tally Health claims > 8000 people (https://tallyhealth....ges/our-science) but I agree with you about the jury being out on its reliability.

 

The other issue is that even the "gold standard" tests completely disagree with each other, so I wonder how one can take any of them seriously.

[Michael Lustgarten]

Tally Health claims > 8000 people (https://tallyhealth....ges/our-science) but I agree with you about the jury being out on its reliability.

 

The other issue is that even the "gold standard" tests completely disagree with each other, so I wonder how one can take any of them seriously.

 

Each of the gold standard tests have their strengths and weaknesses-when viewed through that lens, one can get a pretty good picture for areas to improve or that are currently good. The same is true for blood-based clinical biomarker biological age tests.