NOTE: This does not include Aporphine related alkaloids from other plants although some listed here are also found in other plants. This list was made from reviewing analysis of different Nymphaea and Nelumbo species but mainly Nelumbo nucifera, maybe in the future I might do a bigger list with Aporphines from various plants with their plant sources specified. THIS IS NOT A COMPLETE LIST.
-----Aporphine related-----
Nuciferine (1,2-Dimethoxyaporphine) - Disputed effects on dopamine, Anti-inflammatory, treatment of liver disease in type 2 diabetes, possible Aphrodisiac and Hypnotic effects.
Pronuciferine - Antiviral, increases BDNF protein expression, Impacts glycine-serine-theronine pathway, increases interceller levels of aspartic acid, glutamine and trytophan, , Effects on glucose and inhibit lipogenesis, may help metablic syndrome
Nornuciferine- hERG channel inhibitor, potassium channel inhibitor, inhibits CYP2D6 the enzyme for endongenous, hydroxytryptamines.
Dehydronuciferine - a acetylcholinesterase (AChE) inhibitor
Nuciferine N-Oxidide - Inhibits mellanogensis in mouse, menitoned in a patent for treating bone disease
O-nornuciferine (also known as Floribundine and N-methylasimilobine and 2-hydroxy-1-methoxyaporphine - Calaimed to be the major active ingredient of Chinese traditinal medicine Jiang-Zhi-Ning which is used to regulate cholesterol metabolism
Oxonuciferine/Lysicamine - Oxoaporphine based alkaloids with antioxidant, antimelanoma, antifungal and antibiotic activity
7-hydroxydehydronuciferine - Induces human melanoma cell death in vitro and vivo
2-hydroxy-1-methoxy-6a,7-dehydro aporphine - First discovered in 2012 or 2013?
Anonaine - Aporphine based benzylisoquinoline, selective ruptake inhibitor o D1 and D2, anticancer activity, trypanocidal, antiplasmodial, antiplasmodial.
Dehydroanonaine - Dehydrogenated derivative of Anonaine
Asimilobine - Inhibits dopamine synthesis, believed to be a 5-HT2 receptor antagonist
Lirinidine - Serotoegenic receptor antagonist, Antioxidant, anticancer, inhibits proliferation of melanoma sells, inhibition of melanogensis.
Isoliensinine - Antitumor, cardioprotective, antioxidant, antidepressant, anti-HIV, Anti-type 2 Diabetes. Poor water solubility.
Roemerin (sometimes called Remerine and Aporheine) - Increases BDNF protein expression, effects serotogentic and glutamgeric systems, hypothesized to have antidepressant effect
Caaverine (2-Methoxynoraporphin-1-ol) - Anthelmintic, antioxidant, may interact with the 5-HT2A receptor and the GABA-A (subunit gamma2 and alpha1) receptor.
Cepharadione B - Dioxoaporphine based, Anthelmintic, Antimycobacterial, Antioxidant
----Benzylisoquinoline---
Coclaurine - Nicotinic acetylcholine receptor antagonist
Demethylcolaurine
N-methylisocolaurine
Armepavine - Alpha 1 adrenergic receptor antagonist, May protect against heptic fibrosis, glucose uptake promoter, mentioned in patent for treating bone disease
N-norarmepavine
Higenamine - B2 adrenoreceptor agonist / beta 2 adrenergic receptor agonist, cardiotonic, vascular relaxation, bronchodilator
Juziphine
Norjuziphine
Lotusine - May help protect against Doxorubicin induced toxicicty, Anti-HIV
Dauricine - Inhibits cancer cell growth in vitro, blocks cardic transmembrane Na+, K+ and Ca2+ ion currents
---Other quinolizidine---
Nupharine
Nupharidine - Cysteine inhibition?
alpha and beta-nuphardine
Nuphacristine
Nymphaeine
Nymphaline
---Other---
Nupharamine - Sesquiterpenoid piperidine based
Methylnupharamine
Ethylnupharamine
Naringenin - Flavone based flavonoid
---Amino acids and others (not a complete list)---
Coumaric acid
4-Amino butanoic acid (GABA)
4-hydroxy butanoic acid (GHB)
Threonine
Tyrosine
Phenly alanine
Arginine
Valine
Leucin
Isoleucine
2-amino-7-methyl octanoic acid (amino acid believed to be unique to the Nelumbo and Nymphaea species)
Notes:
There was no Apomorphine or Aporphine itself ever reported in any analysis of plant material I could find, however the NIH did analysis of a reported blue lotus extract resin and found Apomorphine in 1 of 7 claimed samples believed to be a result of by chemical manipulation or faulty testing since it was never repeated.
There is a hypothesis that Aporphine may be internally hydroxylated to form Apomorphine but this has not been definitively proven but would be easy to by scientists due to specific metabolites...
Original Source
