5 replies to this topic

[RubiksKid]

 

What's the consensus? What's the ideal Alpha-Ketoglutarate regimen and how sensitive are the effects to the quality of the product? Any recommendations? 

 

Much appreciated.

[RubiksKid]

I still haven't been able to find an ideal dose; however, I did learn that AKG is rapidly metabolized, so it's necessary to take it in a sustained release form. Also, the evidence supporting its efficacy is more tenuous than I initially thought, but it's also been shown to be safe, so maybe it's worth taking anyway. As it stands, I'm taking 300 mg daily, but it's not a high-priority supplement.

[ironfistx]

Can you elucidate on why its efficacy is more tenacious than you thought?

Edited by ironfistx, 29 March 2023 - 03:29 PM.

[RubiksKid]

Can you elucidate on why its efficacy is more tenacious than you thought?

 

Best summarized here: 

[MikeDC]

My guess is you need high and continuous doses to get rejuvenation effects. Something like a couple of spoons AKG with each cup of water throughout the day.

[QuestforLife]

I still haven't been able to find an ideal dose; however, I did learn that AKG is rapidly metabolized, so it's necessary to take it in a sustained release form. 

 

This is not true. It has been marketed as requiring a sustained released form - but I've used both CaAKG (sustained release) and AAKG (arginine-AKG, fast release) and the reduction on my epigenetic age (measured by methylation markers) were identical for both. I am tracking around 6-7 years under my chronological age. 

 

Now whether this has any bearing on health, is another matter...

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