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33% mouse lifespan increase with Neoagarotetraose

neoagarotetraose

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#1 Decimus

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Posted 02 May 2023 - 06:25 AM


Article: https://www.scienced...090123223001200

It appears this substance is made by depolymerizing agarose. Agarose can be bought via agar powder, which is used as a food supplement and for some medicinal purposes.

https://www.nowfoods...ods/agar-powder


Looks like Neoagarotetraose can also be bought directly here:

https://www.biosynth...eoagarotetraose


I am thinking about taking agar powder from time to time.

Does anyone have any experience with either of these supplements?
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#2 DanCG

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Posted 03 May 2023 - 12:09 AM

It looks like the agarases needed to get Neoagarotetraose from agarose are only found in marine bacteria. So just eating agarose or agar is not likely to work.

 


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#3 Decimus

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Posted 03 May 2023 - 03:49 AM

Interesting. That looks right. I was thinking that the body might metabolize it into neoagarotetraose but that does not appear to be the case, as far as I can tell.

I believe it’s simply an oligosaccharide. Its molecular formula is C18H28O14 which certainly fits a carbohydrate along with the -ose suffix.

Here they are producing it using S Boulardii in vitro but not without some genetic modifications.

https://microbialcel...934-021-01644-w

I would wonder though if other oligosaccharide prebiotics might have a similar effect, such as galacto-oligosaccharides, which are offered online.
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