6 replies to this topic

[Michael Lustgarten]

https://www.youtube....TjNrITUb5M&t=1s

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[albedo]

Thank you Michael.

• At min 3:47, are the ref ranges for older people the same as for younger people? I am always nervous at this issue never clearly researched. At least I do not have it clear... :-(
• I think there is now ample evidence of both Apo-B and Apo-A superiority when comparing to LDL and HDL. https://www.nsfa.ass...nfin-demontree/
• Look also at the ratio Apo-B/Apo-A. "ApoB and the apoB/apoA-I ratio were strong predictors of coronary events in middle-aged men and women, whereas apoA-I did not add significantly to the estimation of future coronary risk." https://academic.oup...26/3/271/487127

 

Edited by albedo, 30 June 2023 - 03:12 PM.

[Michael Lustgarten]

Based on the paper in the video, lower may not be better for people > 60y...

In terms of the ratio, that will likely be in a future video!

[ChooseAName]

Thanks for the video.  It would be surprising if lower was always better.  After all, the lipoprotein exists for a reason.

[albedo]

Based on the paper in the video, lower may not be better for people > 60y...

In terms of the ratio, that will likely be in a future video!

 

Thank you Michel, I realize that. My criticism was I admit a bit general. I cannot make my mind around (say) things like hormones: would (say) a free testosterone reference range for 25 yo man applicable to a 65 yo man? I guess not. Often ref. ranges are not differentiated for the labs making the assays.

[Michael Lustgarten]

Thank you Michel, I realize that. My criticism was I admit a bit general. I cannot make my mind around (say) things like hormones: would (say) a free testosterone reference range for 25 yo man applicable to a 65 yo man? I guess not. Often ref. ranges are not differentiated for the labs making the assays.

 

No worries albedo. I'd say yes, but only if the youthful testosterone levels for someone of advanced chronological age is also within the context of many other youthful biomarkers. I think it can be a problem for health if that's not the case.

[albedo]

No worries albedo. I'd say yes, but only if the youthful testosterone levels for someone of advanced chronological age is also within the context of many other youthful biomarkers. I think it can be a problem for health if that's not the case.

 

Yes, that is a good point. Individual BM are important guidelines for clinicians while looking for more global and far reaching composite indexes, incl. all sort of "omics", better capture the process of aging, its slowing down and hopefully reversal.