2 replies to this topic

[Furniture]

Does anyone know of an accessible & affordable source of Scyllo-Inositol? I'm very interested in buying some (ideally somewhere between 10 to 200 grams, depending on the price), but there doesn't seem to be an easy way to get a hold of this simple compound....

 

The only way to purchase it, I've found, is through chemical vendors that rarely sell to individuals, mostly just research facilities. They sell it at exorbitant prices anyways (just 25mg can cost over $100). There's also one vendor on Alibaba that claims to sell 98% pure Scyllo-Inositol. However, they sell it by the kilogram, each kilogram costs $1,000, and the company has zero reviews or gives any indication that they're a legitimate, trustworthy company.

 

 

For those of you who are curious about scyllo-inositol:

 

Scyllo-inositol is a naturally occurring stereoisomer of Inositol (the most common being myo-inositol). It's present in many fruits, usually in just trace amounts but grapefruit juice contains up to 15mg/100g (https://www.scienced...308814603006265). Scyllo-Inositol is currently being studied as an Alzheimer's treatment because of its ability to inhibit Amyloid-Beta aggregation:

 

Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer’s disease: a systematic review

 

https://www.scienced...568163721002439

 

"Scyllo-inositol (ELND005, Phase II, completed/discontinued) is a naturally occurring stereoisomer of inositol that easily crosses blood brain barrier (Liang et al., 2013, McLaurin, 2010). It is a small-molecule inhibitor of Aβ aggregation. Preclinical studies gave promise, since they showed its ability to stabilize small Aβ complexes. Increasing the hydrophobicity of scyllo-inositol by the addition of two methoxy groups (1,4-di-O-methyl-scyllo-inositol) stabilized Aβ42 protofibrils in vitro, attenuated spatial memory impairments and significantly decreased cerebral amyloid pathology in TgCRND8 mice with amyloid pathology (Fenili et al., 2007, Hawkes et al., 2010, Ma et al., 2012). Further long-term clinical studies in patients with AD will be needed in order to obtain evidence sufficient to demonstrate or rule out any beneficial effects of scyllo-inositol as treatment for AD."

 

 

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

 

https://www.ncbi.nlm...les/PMC6672572/

 

"From a therapeutic perspective, we show that a monoclonal antibody against the Aβ N terminus fully prevents the effects of soluble oligomers on dendritic spines. The same antibody prevented the effects of acute Aβ oligomer exposure on hippocampal LTP in vivo (Klyubin et al., 2005), suggesting that passive immunotherapy could slow the progressive perturbation of synapse structure and function in patients with mild AD and its precursor, mild cognitive impairment (MCI). Similarly, we find that scyllo-inositol prevents the effects of natural Aβ oligomers on dendritic spines, suggesting that this and similar compounds may be of therapeutic benefit in the treatment and prevention of mild AD. A recent report showed that the oral administration of scyllo-inositol decreases plaque count and Aβ oligomer levels in the TgCRND8 mouse model of AD (McLaurin et al., 2006). Performance in a spatial learning task also improved, consistent with our finding that scyllo-inositol prevents oligomer-induced synaptic perturbations in the hippocampus. We recently found that scyllo-inositol binds natural Aβ trimers without depolymerizing them and apparently prevents their actions on neuronal targets (Townsend et al., 2006b), consistent with the reported binding and stabilization of small oligomers of synthetic Aβ by the compound (McLaurin et al., 2000)."

 

 

 

Many isomers of inositol are naturally occurring (myo-inositol, d-chiro-inositol, l-chiro-inositol, scyllo-inositol, muco-inositol, and neo-inositol), but some can only be produced synthetically (allo-inositol, cis-inositol, & epi-inositol)

 

Scyllo-inositol is one of the naturally occurring isomers and is found in many foods we eat every day. But for some reason you cannot buy it as a supplement, unlike Myo-Inositol & D-Chiro-Inositol which are easily attainable and commonly used to treat depression, PCOS, & OCD.

 

If anyone knows of a legitimate source, or can guide me in the direction of one, please let me know!

 

Thank you,

 

 

 

Edited by Furniture, 16 December 2023 - 11:17 PM.

[Daniel Cooper]

I saw that study and am interested in Scyllo-Inositol for the same reasons as you.

 

Unfortunately - I also haven't found a source that will sell to the public and is affordable by mere mortals. 

 

But .... once a study like that comes out on an issue that most people care about (avoiding Alzheimer's) you tend to see the supplement industry respond in 6-12 months by introducing new products to meet the demand. So I'm hoping this will unfold like that in the next year or so.

 

 

[Furniture]

I saw that study and am interested in Scyllo-Inositol for the same reasons as you.

 

Unfortunately - I also haven't found a source that will sell to the public and is affordable by mere mortals. 

 

But .... once a study like that comes out on an issue that most people care about (avoiding Alzheimer's) you tend to see the supplement industry respond in 6-12 months by introducing new products to meet the demand. So I'm hoping this will unfold like that in the next year or so.

 

You would hope it would be that quick, but it looks like the connection between Scyllo-Inositol & Amyloid-Beta oligomers has been known since at least 2000. Maybe even earlier (I didn't do a deep dive into the research):

 

Volume 275, Issue 24, 16 June 2000, Pages 18495-18502

PROTEIN STRUCTURE AND FOLDING

Inositol Stereoisomers Stabilize an Oligomeric Aggregate of Alzheimer Amyloid β Peptide and Inhibit Aβ-induced Toxicity

https://www.scienced...02192581983212X

 

"Negative stain electron microscopy analysis of Aβ42 demonstrated that when Aβ42 is incubated in buffer, fibrils were of varying lengths (Fig. 4 A). In the presence ofchiro-inositol, the Aβ42 fibers were indistinguishable from Aβ42 alone (Fig. 4 B). In contrast, no fibrils could be detected in the presence of epi-inositol (Fig.4 C) and scyllo-inositol (Fig. 4 D) demonstrating an activity similar to myo-inositol (38). The fine thread-like structures detected in the Aβ42-epi- andscyllo-inositol samples were present in the inositol solutions alone and therefore not Aβ fibrils. These results demonstrate that although epi- andscyllo-inositol are able to induce β-structure in Aβ42, the Aβ42-inositol complex does not progress to form fibrils. Similar to that reported for myo-inositol, Aβ42 can form stable β-structured, non-fibrillar complexes with epi- andscyllo-inosito"

 

"It was surprising to find that when Aβ40 was preincubated in the presence of epi- and scyllo-inositol, these mixtures increased the cell survival of PC-12 cells from 56 to 93% and 83%, respectively (Table I). Preincubation of Aβ42 withepi- and scyllo-inositol increased cell survival from 54 to 89% and 83%, respectively. Preincubation of Aβ40 with various concentrations of epi- andscyllo-inositol resulted in attenuation of toxicity as low as 1:1 Aβ:inositol ratio (by weight; Table I). Similar results were seen when Aβ42 was preincubated with the stereoisomers (Table I). In contrast, chiro-inositol preincubation did not rescue PC-12 cells from either Aβ40- or Aβ42-induced toxicity with neuritic dystrophy similar to Aβ treatment alone (Table I). The ability ofepi- and scyllo-inositol to attenuate toxicity when preincubated at low concentrations suggests that the Aβ-inositol interaction is specific."

 

 

I'm not sure why the supplement industry hasn't picked up on this one. Could Scyllo-Inositol be uniquely difficult/expensive to produce? I would think not, since it's a simple compound and both Myo-Inositol & D-Chiro-Inositol are available over-the-counter for relatively cheap. But I'm not a chemist so who knows?

Edited by Furniture, 20 December 2023 - 06:01 PM.