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Biomarkers Of Kidney Function: Creatinine, Cystatin C, What's Optimal?

blood testing

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#1 Michael Lustgarten

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Posted 11 February 2024 - 12:16 PM


https://www.youtube....h?v=RM-dQZj3h6U

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#2 albedo

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Posted 17 February 2024 - 11:32 AM

Well researched Michael. You let me realize once more the importance of Cystatin C and RDW association to risk (in the Bortz 2023 study and your nice chart reproduced below) and biological age. I recollected also RDW as largest weight in the Levine's Phenotypic Age BA formula as you also mentioned.

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BTW I keep measuring since at least 10 years (I am now 70) eGFR based both on Cystatin C alone as well as the combination of Creatinine + Cystatin C. At 70 my values are 89.6 and 85.5 respectively. Note also that the Nat Kidney Foundation - https://www.kidney.org/ changed in 2021 the formulas based on new studies. They provide both 2012 and 2021 formulas: the eGFR values differ, e.g in my case the combination value is 80.4 (formula 2012) vs 85.5 (formula 2021).


Edited by albedo, 17 February 2024 - 11:48 AM.


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#3 albedo

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Posted 19 February 2024 - 06:33 PM

Michael, sorry if I am overlooking (again!) but, in terms of the value of Cys-C, what is the value of it associated to the mid survival curve (10-90% percentile)?

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#4 Michael Lustgarten

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Posted 19 February 2024 - 07:10 PM

No worries albedo, 0.7 - 1.08


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