Im going to take a break from nicotine. I have been off nicotine for 36 hours. Almost all my muscle aches, stiff neck and brain fog feel gone. I think the muscle pains were from working out but were definatly a lot worse than usual. I think they stem from the vasoconstriction and poor bloodflow in general. Perhaps stiffness from acetycholine.
I read therombine may be a vasodialtor. I took a really low dose of ginkgo at 30mg. I don't know if a vasodialtor on its own could change vasoconstriction from all other pathways and noradrenaline. I measured my blood pressure today and it is normal. I didn't measure while on nicotine. But 5mg of propranol helped my symptoms.I will probably try another protocol I have been using to hope to continue to improve after my chronic brain injury.
Nicotine does work so well for OCD symptoms. I also noticed I scored noticeably higher scores in my brain training games. I did a couple hours reading on this site. I guess nicotine has been tried for adhd and alzhimers, skitzophrnia ect. There was a partial agonist of the nicotinic a7 receptor or something that was developed as an antidepressant that may have been beneficial to some user's protocols here. It was never marketed under name was conitine or continine fumaric acid. It can be purchased, perhaps if you have a University address. It sounded like partial agonist maybe like galantmine maybe mematine. User's reported they are not that effective on thier own for cognition, so I wouldn't be sure about ocd for myself. But maybe to aid metabolisim or for an alkinizing protocol. They have been paired with racetoms for cogniton and nicotine or to lessen tolerance and such.
I learned some possible ideas to lessen nicotine side effects in the thread called Nicotine and VasoconstrictionApparently the patch may have less vascontrictive properties. Perhaps it some how bypassing endothelin-1 (ET-1) receptors. I get confused with receptors and pathways. Also melatonin may offset some of the negative effects to tissues. A few years ago, for a few mpnths I trialed a slow release dose of 300mcg Melatonin during the day. I felt nothing but it may not be healthy for Endocrine system long term I imagine.
In the same thread it was stated that red wine removed the rise in blood pressure. I believe I took low dose reversatrol when I tripled nicotine before. It might have helped. I don't take notes I dont know if I took nicotine daily or few days a week. I didnt get sore muscles back then, but I also just started working out this time around. I might try fish oil and culturelle with resveratrol and perhaps cut strips off of nicotine patches. However, I believe thier more expensive. I'm not overly confident, since haven't read any cases of any user completly solving the vasoconstriction or potential sleep issues with nicotine use.
Edited by bullGenteel, 20 November 2025 - 06:18 AM.
