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[Galaxyshock]

I take Life-Extension Two-Per-Day multivitamin again, it feels superior to other multis, I particularly like the methylated B-vitamins. I notice better energy and mental clarity from it.

 

However, there's some corcern that the big amount of vitamin B6 could be problematic as there's speculation high amount of B6 may cause neuropathy?

 

Should I be concerned with this as there appears to be two forms of B6 in this multi:

 

Vitamin B6 (as pyridoxine HCl, pyridoxal 5'-phosphate) 75 mg 4,412%

 

I could of course only take one capsule per day so it would be 37,5 mg of B6.

[pamojja]

Take 1 two-per-day LEF daily since many years. And add about 1-3 of their expensive Mix multi tablets. On the ME/CFS forum, there are a few, which don't tolerate even such small, or any amount of pyridoxine. While I always (since 16 years) used in average 170 mg a day, including about half as P-5-P.

 

The problem of neuropathy from pyridoxine started, when the EU outlawed anything above 25 mg/dose. Therefore, I upped the pyridoxine fraction for the first time above 100 mg/d, exactly 130 mg/d, for one year from an old long expired bottle. Which for the first time caused left-sided neuropathy for me.

 

Reducing again to the 45 mg/d from LEF multis, and increasing P-5-P to 130 mg/d instead, did gradually improve the neuropathy again. Took more than a year.

 

Though I usually always follow the advice to increase doses gradually, so that side effects are caught early, in this 1 case I didn't.

 

https://www.sunday.d...amin-b-komplex/ would provide all B-vitamins in better forms. But their multis don't compare to LEFs.