I am an ardour taker of phenibut. I take 1-2grams per day. The best result is 1g per day. If taking more than 1g you don't feel more euphoria. After 2 days of taking phenibut it acts weaker. Phenibut downregulates gaba receptors while afobazol upregulates them. So what's the best regimen to cycle phenibut with afobazol? 2 days on phenibut followed by 2 days of afobazol? Also are there any substances to increase effect of phenibut? I additionally take pill of korvalol (phenobarbital+valeriana) before sleep to induce more sleepiness. Adding korvalol to phenibut during day weakens euphoria from phenibut? Any ideas? Any boosters of phenibut?

Best way to upregulate gaba receptors
#1
Posted 09 September 2025 - 09:40 PM
#2
Posted 10 September 2025 - 08:33 PM
New impotant info! today i have experienced giant boost of phenibut action from vit c! I wrote yesterday about developing tolerance to phenibut after using it during a week with 1-2g per day but today i accidentally took 1g of vit C in addition to second daily dose of 1g at noon (first 1g dose was taken in the morning) and voila: the effect was that i almost fell asleep and this utter sleepiness lasted 4 hours. So, either i lacked vit c in the brain or it possesses the ability to upregulate gaba receptors. I am going to continue taking this mix to find out the truth.
Action of phenibut+vitc still continues after 7 hours. My vision is kind of foggy, i feel hot like after good alcohol, blood vessels are widened.
Anyway, my new theory based on 1964 soviet book kind of contradicts the bullshit about receptors as the book says nothing about receptors at all while considering neuromediators substantially. Ok, the theory is that phenibut (and perhaps all/some psychodelic/stimulating) drugs deplete some vital substances in brain like vitC for example. Does it mean that you can take morphine, heroin, cocain every day without bad consequences? It can be, you should check if you have those banned drugs.
#3
Posted 11 September 2025 - 03:21 AM
Fasoracetam supposably upregulates GABA-B through modulation of metabotropic glutamate receptors. Some report it bringing the Phenibut "magic" back.
Note though, Phenibut is also a gabapentinoid (calcium channel blocker) and TAAR1-receptor antagonist, so it isn't simply just a pure GABA-B agonist like Baclofen.
#4
Posted 11 September 2025 - 10:28 AM
Thanks for info though in Russia only piracetam is sold among racetams.
A little more about my theory on non-existance of mythical up/downregulation of receptors: i suppose that body percieves concentrated substances swallowed or injected as hostile agents (kind of a poison) and produces "antibodies" i.e. substances blocking action of those "poisons". The simple way to reanimate action of poisons is to destroy antibodies which means finding appropriate killers of antibodies. The existing and approved theory about physical changes in nerves (receptors) seems false to me. why would body as integrated homeostasysical system would adapt itself to external taken substances? I think it's easier to go the aforedescribed way.
#5
Posted 11 September 2025 - 11:01 AM
My theory is also proved by info from the aforementioned book which states examples when some neuroleptics instead of supressing action of psychostimulating drugs kind of modified their action which means that though different neuroleptics though aimed at adressing the same group of receptors actually produced different result and all this happens because those neuroleptics (as well as any other psychodrugs) are split into perhaps hundreds of metabolites which simply cannot be studied by existing sxientific tool and judging from the fact that attempts to find out the cause of shizophrenia (and other neurodisorders) were already abandoned in 60s we may conclude that now the plight of matters is no better and that false theories like that about 3 monoamines regulating our mood have been forced on us, intentionally disseminated and are misleading from the truth.
#6
Posted 11 September 2025 - 11:48 AM
Thanks for info though in Russia only piracetam is sold among racetams.
A little more about my theory on non-existance of mythical up/downregulation of receptors: i suppose that body percieves concentrated substances swallowed or injected as hostile agents (kind of a poison) and produces "antibodies" i.e. substances blocking action of those "poisons". The simple way to reanimate action of poisons is to destroy antibodies which means finding appropriate killers of antibodies. The existing and approved theory about physical changes in nerves (receptors) seems false to me. why would body as integrated homeostasysical system would adapt itself to external taken substances? I think it's easier to go the aforedescribed way.
That's pretty interesting idea. We also know that sometimes a familiar scent or something a person sensed during the influence of a drug such as cocaine can trigger them to feel as if they are suddenly intoxicated on said drug without having the chemical in their system anymore. So the brain remembers the neurotransmitter firing the drug caused and can replicate the experience given circumstances. Some speculate Memantine can be used to prevent the brain from "programming" the drug action to the brain and the prevention of drug tolerance from Memantine is at least partially caused by that.
#7
Posted 13 September 2025 - 01:43 PM
Some sad news as follows: vitC unfortunately is not the tolerance killer for phenibut. It caused sleepiness because I had lacked it in brain evidently. It no longer helps to arouse any effect on psyche.
As for phenibut of russian make that i have been taking last week it's kind of strange. It caused more sleepiness than feeling of light pouring from medium around that i had from american phenibut in 2012. I suspect that actually they sell smth like blockator of calcium channels instead of phenibut.
Re my theory above: any psychodelic drug changes perception to non-normal which is non-beneficial for survival, therefore organism tries to restore normal perception for which reason any psycho drug causes tolerance and this tolerance is physically implemented in production of counter-substances (for example exciting ones for depressing drugs) , that's why you have withdrawal. I suspect that it's not possible to stop such process as the more you try by increasing the dose the more withdrawal you will have, though theoretically it's possible to eliminate produced exciting counter-substances but by which drugs? I suspect those counter-substances are not even known as they may have very complex organic structure. If receptor theory is right countersubstances may block feed of the drug to synapses for example or just come into chemical reaction with it.
I badly need new drug, phenibut is useless now, and i have war against villains on my floor in the multistoreyed building who all united against me.
Memantine is not sold in Russia, nor adderall, etc., only crap is sold. I want to try atropin. What would you say? I was diagnozed ishemia at 18 years old (may still have it) but atropin should not be taken with ishemia and fast pulse which i also have. Any ideas how to survive in russia?
#8
Posted 13 September 2025 - 11:20 PM
In my experience the effects of Phenibut can vary depending on tolerance, dosage and just randomly. Sometimes it would induce very nice euphoria and anxiolysis, sometimes horrible sleepiness and the withdrawals from extended use can be brutal. I used Phenibut years ago for the anxiolysis but the fluctuating effects and dependency were definitely not worth it. It's also a pain in the ass to dose it as it can take up to 5 hours for the effects to start.
Yeah it's very possible the body produces "counter-substances" to intoxicating drugs and also perhaps lowers the amount of endogenous ligands. I mean there seems to be endogenous equilavent to many drugs of abuse: amphetamines - phenylethylamine, benzodiazepines - endozepines, opioids - endorphins etc.
Is Kava available in Russia? In my experience it's perhaps the least harmful psychoactive.
#9
Posted 14 September 2025 - 09:20 PM
I don't think that kava is sold in Russia, they have even banned mb! I think i will try atropin 1mg per day if they sell it to me without prescription.
The effect from american phenibut was always stable as poring light. One brand of russian phenibut was also good in 2010. Some other russian or belorussian brand was also magical in 2010 - it made me go home on foot at night instead of by transport to enjoy fresh air and lights of lanterns at night. As i have written before they have removed all psychodelic effects from drugs here. Present-day's phenibut produces sleepiness for me. Ciltep stack made me go for a walk in the evening couple of months and write a book. Of course substances for ciltep stack were ordered from usa. Now we can order only some crap from china, not even drugs.
#10
Posted 14 September 2025 - 11:36 PM
Well that's unfortunate. Kava got the reputation of being harmful to liver because they sold poor quality extracts that contained leaf parts of the plant back in early 2000s. So they banned it in many countries and haven't even bothered to remove the ban despite research showing it doesn't harm the liver if only the root parts are used (the traditional way). Pharmaceutical companies probably like it so they can push crap drugs like Quetiapine for anxiety and make profit.
Do you have experience with adaptogens? They tend to work very well for some people to help cope with stress. Siberian Rhodiola is an effective one.
The counter-substance theory got me thinking perhaps taking substances that initially feel unpleasant can cause a rebound effect of drug-like feel good buzz. Low dose Naltrexone kinda works that way, it upregulates endorphin production. Then there's Salvia which is kappa-opioid agonist and dysphoric but causes nice afterglow to users.
#11
Posted 15 September 2025 - 07:55 AM
Yes, this theory seems to work and your words add to this camp. Another example is that before fight boxers have increased adrenaline because of fright but it transforms into noradrenaline (feeling of godlike selfcontrol) during fight, i guess mountainclimbers have similar process but more extended in time. Pianists before and after concert is another example.
I have tried rhodiola pink as they call it here. Couple of times i observed energy boosting effect but then it just stopped producing any effect, both rhodiola and especially ginseng giving heart ache for me. I had good experience from selegiline (no longer sold in russia since about 2010) though it gave overexcitement and not pleasant feelings in heart in several days after taking.
More about rebound effect: barbiturates such as phenobarbital supress electrical activity in brain (works like depressive substance) and if overdosing for extended period like with alcohol you get psychosys delirium (with hallucinations and strange behaviour) after abrupt withdrawal as rebound effect. Same with sport: movement and weights cause damage to joints and release of endorphines as countersubstance. Sport is the most irrational and harmful crap and it never extends life or health viewed in the context of long-term period. Playing modern musical instruments harms joints as they make them with 2 times havier down key action or heavier to hold (woodwinds) or damn thick strings for guitar. The idea is to let consumers buy expensive pro models or to damage their health or to discourage them from training or all of the above. Their idea is life shortening by all means.
Edited by mbdrinker, 15 September 2025 - 08:22 AM.
#12
Posted 15 September 2025 - 08:17 AM
Another practical example for the theory: if you eat a lot of good bitter garlic you get some mild improvement of mood, same works with pepper and other spices and their is no tolerance to them. One of the reason can be that they are disphoric antagonists of euphory substances produced in rebound. Their action differs from heroin, cox and similar drugs which are metabolized into endorphines and pleasing amines themselves but as homeostasys system body strives to return to neutral state. It also has much to do with stimulus-reaction principle of psyche functioning (for the aims of survival in environment): pleasant reward must be given only for some labour,pain,suffering and other muscle orbrain straining experience.
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