Researchers here present a list of open problems in aging research, mined from the literature and outreach to the scientific community. This is certainly a topic on which opinions differ as to which of these areas of research are more or less important than others. An assessment of literature and community will tend to capture these differences of opinion, and ongoing debates over the best course ahead. In large part the diversity of opinions reflects the lack of a consensus measure of aging that can accurately assess the outcome of a potentially age-slowing or rejuvenating intervention. If such a measure existed, there will likely be little debate over the best path forward.
Despite advancements, the field of longevity science is at a crucial point as it continues to face numerous open problems that hinder further progress. Recent works have highlighted fundamental knowledge gaps and strong disagreements amongst scientist studying ageing. Addressing these challenges is critical for unlocking new insights and developing effective interventions to extend both lifespan and healthspan.
We now present a new list of 100 open problems in ageing science, identified and curated through a combination of community engagement and text-mining approaches. These problems span a wide range of topics, from molecular biology and comparative approaches to translational efforts and clinical applications. By outlining these 100 problems, we aim to guide and provide goals for future research and map the key areas where knowledge gaps exist.
These open problems are presented on our website (https://longevityknowledge.app), where users can interact with and find more information on each selected problem.
Link: https://doi.org/10.1007/s11357-025-01964-4
View the full article at FightAging
