By Vince Giuliano with important inputs from Gemini 3, ChatGPT 5 and Copilot
12-5-2025
PREFACE
This is the Second Part of a two-part series of blog entries. The First Part MECHANISMS OF AGING AND INTERVENTIONS FOR LONGEVITY PART 1 THE FIRST 100 YEARS describes causal processes of human aging, as typical from birth to approximately 100 years of age This description provides a comprehensive framework that is sufficient to explain all known aspects of human aging. The First Part also outlines interventions and activities that can help fundamentally healthy people have a high likelihood of reaching 100 or so years of age, healthy, functional, and cognitively all there. Some people, possibly many, may be able to continue working and contributing to their families and society for a few years more. The First Part also lays out important distinctions, and I suggest that reading it is a prerequisite to understanding what follows here.
This current Part Two entry is divided into two Halves. The First Half is concerned with additional topics and interventions related to successfully getting through the first 100 years of life: AKG and Klotho. The Second Half is concerned with more-recent research on certain longevity interventions that show promise of working for people who have survived their first 100 years in a healthy, highly functional state. I am referring to approaches that involve Younging, that is, whole-organism regression to a previous younger state. Finally, I discuss the possibility of transferring a surrogate of me into AI entities such as humanoid robots, enabling that surrogate to continue experiencing living and have a lifespan of hundreds or more years.
FIRST HALF: ADDITIONAL TOPICS AND INTERVENTIONS RELATED TO GETTING SUCCESSFULLY THROUGH THE FIRST 100 YEARS OF LIFE
These are topics I have recently been concerned with and need to be viewed in the context of the topics already covered in Part One.
- ALPHA KETO GLUTARATE (AKG)
Image source
Here is a detailed breakdown of its proposed health and longevity benefits.
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