2 replies to this topic

[timedilation]

This popped up in one of my feeds, but I don't think I've seen it discussed before:

 

https://www.prnewswi...-302656482.html

 

 

Immorta Bio Inc., a scientific longevity company dedicated to Treating Diseases of Aging and Treating Aging as Disease™, today announced new data demonstrating that its combination therapy of SenoVax™, a first-in-class senolytic immunotherapy, and personalized mesenchymal stem cells (pMSCs) from its breakthrough StemCellRevivify™ platform, doubled lifespan and significantly extended healthspan in validated murine aging models.

 

Pretty exciting if it holds up.  This is exactly the type of approach I've been waiting for.

[dlewis1453]

Yes, this is very exciting. I will hold back excitement until they publish the full paper, but if this research holds up it will show what many of us here at Longecity have suspected - that removing senescent cells on its own is not sufficient to have a big impact for longevity. You need to remove them and provide replacements. The stem cell treatment mentioned in the pr release provides the replacement. Interestingly, the stem cell treatment uses stem cells cultured from your own tissues, which solves the problem of the immune system rejecting the integration of foreign stem cells into the body. 

 

One thing I did not in the pr release is that these mice were not naturally aged. They were damaged via two common induced aging models - carbon tetrachloride (CCl₄)–induced liver injury and doxorubicin-induced systemic senescence.

[Mind]

Nice result...in genetically modified mice.