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Supplements I take for liver health and muscle gain


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#1 Hope47

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Posted 03 May 2026 - 09:39 AM


Supplements I take for liver health and muscle gain

 

Glycine 10 gm daily( removes fat buildup from liver)

*NAC -600mg( also good for liver)

*TMG 2-3gm daily(stopping it soon)

*Boron 6 mg daily( to increase free test)

*Vitamin D3 10k Daily( low, don't go out in the sun much, thinking of taking it twice weekly)

*Whey Protein( not able to hit daily target protein intake )

*Creatine 5gm ( for strength)

*Preworkout with 200 mg caffeine and other amino acids.(for pump)

I lift weight 4 times a week and 30 minutes cardio. I am overweight btw. Do you think these are too much? I am 5'10'' and 39 yr old male, 90 kg weight .I was a former alcoholic for years with lots of liver fat/damage. What do you guys think? What should I remove? Help!


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#2 Blueflash

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Posted 20 May 2026 - 06:19 PM

I'd be careful with NAC. Believe it depleted some minerals on me and caused heart palpitations. Citrulline and horny goat weed give major pumps. Zinc might be worth adding. And maybe ashwaghanda (careful with it. It's not for everybody. Raises serotonin or something) Maybe look into vitamin K2 MK4 to keep calcium where it belongs since you are using vitamin D.Good luck!


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#3 Dorian Grey

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Posted 26 May 2026 - 02:10 AM

The polyunsaturated fraction of Lecithin/phosphatidylcholine, known as PPC or polyenylphosphatidylcholine (supplement brand PhosChol from Nutrasal / prescription brand Essentiale Forte / Sanofi) has some remarkable antifibrotic properties and is a top-tier liver repair aid.  Look Here: 

 

Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon  PMID: 8276177

 

The above trial was for protection in drinking populations, but its antifibrotic properties might be of interest in recovery also: 

 

Polyenylphosphatidylcholine (PPC) is an active, highly purified soybean extract exhibiting strong antioxidant, anti-inflammatory, and antifibrotic properties. It works by replenishing damaged cell membranes, inhibiting oxidative stress enzymes, and blocking pro-fibrogenic genes in hepatic stellate cells

 

You might also wish to look into SAM-e S-adenosylmethionine, which is also a potent liver anti-inflammatory / aid, giving glutathione building blocks pre-assembled.  When I used to drink, this was my go-to hangover cure, but livers love it even if you're drinking days are over.  Be very careful with SAM-e if you're Bi-Polar or on SSRI meds, as SAM-e can boost serotonin. Do not risk serotonin syndrome! The standard dose is 400mg, but I seek out the 200mg tabs and only take 2/day on empty stomach.

 

------------------------------

 

Also...  I've become very interested in Ferrotoxic Disease (age related iron accumulation), and Alcoholic Liver Disease actually has a substantial iron component, as drinking increases absorption of dietary iron and iron is stored in the liver, which can cause inflammation when large amounts accumulate over time.  

 

Ferritin is a dirt cheap blood lab that gives a good measurement of stored iron.  The upper limits for the normal range are set quite high, at around 300 for men, but this is the threshold for clinical iron overload and NOT optimal health.  Ideally, you'd like to see ferritin in the 50-100 range, particularly if you're trying to minimize liver inflammation, though anything under 150 is probably reasonably safe.  

 

The body has no way of eliminating excess iron, so once you've gotten loaded up, blood donation (WHOLE BLOOD, the iron is in the red cells) is the only way to dump large amounts of iron in a short time.  If blood donation is not for you, CURCUMIN can help chelate iron, but it's a long slow process.  It will however lower inflammation fairly quickly, which would be a good way to see if any ferritin elevation is inflammatory or not.  If curcumin gives a noticeable improvement, you'll know iron reduction needs to be a top priority.  

 

The rest of your stack certainly seems reasonable enough, though I'd go easy on the protein powder.  All things in moderation and...

 

Best of Luck to you! 

 


Edited by Dorian Grey, 26 May 2026 - 02:43 AM.

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#4 elc202

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Posted 02 June 2026 - 02:30 PM

The polyunsaturated fraction of Lecithin/phosphatidylcholine, known as PPC or polyenylphosphatidylcholine (supplement brand PhosChol from Nutrasal / prescription brand Essentiale Forte / Sanofi) has some remarkable antifibrotic properties and is a top-tier liver repair aid.  Look Here: 

 

Phosphatidylcholine protects against fibrosis and cirrhosis in the baboon  PMID: 8276177

 

The above trial was for protection in drinking populations, but its antifibrotic properties might be of interest in recovery also: 

 

Polyenylphosphatidylcholine (PPC) is an active, highly purified soybean extract exhibiting strong antioxidant, anti-inflammatory, and antifibrotic properties. It works by replenishing damaged cell membranes, inhibiting oxidative stress enzymes, and blocking pro-fibrogenic genes in hepatic stellate cells

 

 

 

Hi Dorian,
I hope you don't mind me asking, but I remember a few years ago you mentioned that you had a blood test for some kidney function,  and you did not like the results. Did you get it fixed? and how so? does PPC help with aging kidneys?

and since it comes from soybeans, aren't there problems because of phytoestrogens?

Thanks,



#5 Dorian Grey

  • Location:kalifornia

Posted 02 June 2026 - 03:54 PM

Hi Dorian,
I hope you don't mind me asking, but I remember a few years ago you mentioned that you had a blood test for some kidney function,  and you did not like the results. Did you get it fixed? and how so? does PPC help with aging kidneys?

and since it comes from soybeans, aren't there problems because of phytoestrogens?

Thanks,

 

Hi elc, & yes my kidney function fell a bit in my last set of labs, not critically low, but I'm turning 70 this year, so just old man lab range I hope.  eGFR dropped from 82 down to 72.  Anything over 60 is supposed to be normal range.  

 

PPC is supposed to be the ultimate "membrane therapeutic" and the kidneys are primarily one huge membrane, so theoretically PPC should be a top tier kidney therapeutic.  This said, I had been taking PPC for over 10 years, and my kidney function did drop a bit. I was dosing moderately, at 1200mg/day, and I've also been a Joe six-pack drinker my entire adult life, so this might have dinged my kidneys a bit despite the PPC.  

 

Nutrasal has some info on the purity of their product here: https://nutrasal.com...pc-product-page

 

There is also a pharmaceutical PPC product: Essentiale Forte / Sanofi.  From what I've seen, there is only one source for PPC, which is a company in Germany, so I'm assuming Sanofi gets their PPC from the same place as Nutrasal (or anyone else).  Dare we assume it is all pharmaceutical grade?  

 

The ONLY downside I've ever seen to PPC is the possibility it may feed gut microbes that generate Trimethylamine, which the liver oxidizes into TMAO, which is supposed to be inflammatory to vascular endothelium, potentially contributing to coronary artery disease.  I had read that so long as kidney function is normal, TMAO is quickly and safely removed, but when kidney function declines, this could cause trouble. I've also read berberine will effectively kill off the evil bacteria that generates the TMA, so this might be a work-around if you wish to eliminate any TMAO risk from PPC.  

 

Nutrasal also has a statement PPC does NOT raise TMAO...

 

https://nutrasal.com...X0dhgjuq8-mUpBY

 

Studies Confirm PPC Does Not Raise TMAO  But this appears to be based on a lack of proof rather than an actual proper study actually looking for a PPC . TMAO connection.  

 

After 2 COVID vaccines (J&J) and 2 COVID infections, I suddenly found I had developed exertional angina, and low and behold my kidney function had declined a bit during this time.  Was it the COVID?  The vaccines?  Or the PPC / TMA / TMAO connection?  

 

Don't know, but this is all I've learned on the matter.  Best of Luck and Stay Healthy!  


Edited by Dorian Grey, 02 June 2026 - 04:25 PM.

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#6 elc202

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Posted 02 June 2026 - 08:26 PM

Hi elc, & yes my kidney function fell a bit in my last set of labs, not critically low, but I'm turning 70 this year, so just old man lab range I hope.  eGFR dropped from 82 down to 72.  Anything over 60 is supposed to be normal range.  

 

PPC is supposed to be the ultimate "membrane therapeutic" and the kidneys are primarily one huge membrane, so theoretically PPC should be a top tier kidney therapeutic.  This said, I had been taking PPC for over 10 years, and my kidney function did drop a bit. I was dosing moderately, at 1200mg/day, and I've also been a Joe six-pack drinker my entire adult life, so this might have dinged my kidneys a bit despite the PPC.  

 

Nutrasal has some info on the purity of their product here: https://nutrasal.com...pc-product-page

 

There is also a pharmaceutical PPC product: Essentiale Forte / Sanofi.  From what I've seen, there is only one source for PPC, which is a company in Germany, so I'm assuming Sanofi gets their PPC from the same place as Nutrasal (or anyone else).  Dare we assume it is all pharmaceutical grade?  

 

The ONLY downside I've ever seen to PPC is the possibility it may feed gut microbes that generate Trimethylamine, which the liver oxidizes into TMAO, which is supposed to be inflammatory to vascular endothelium, potentially contributing to coronary artery disease.  I had read that so long as kidney function is normal, TMAO is quickly and safely removed, but when kidney function declines, this could cause trouble. I've also read berberine will effectively kill off the evil bacteria that generates the TMA, so this might be a work-around if you wish to eliminate any TMAO risk from PPC.  

 

Nutrasal also has a statement PPC does NOT raise TMAO...

 

https://nutrasal.com...X0dhgjuq8-mUpBY

 

Studies Confirm PPC Does Not Raise TMAO  But this appears to be based on a lack of proof rather than an actual proper study actually looking for a PPC . TMAO connection.  

 

After 2 COVID vaccines (J&J) and 2 COVID infections, I suddenly found I had developed exertional angina, and low and behold my kidney function had declined a bit during this time.  Was it the COVID?  The vaccines?  Or the PPC / TMA / TMAO connection?  

 

Don't know, but this is all I've learned on the matter.  Best of Luck and Stay Healthy!  

 

Thanks,
I think the cheapest option is LE (HepatoPro) on iherb. They have the same 900mg dosage per softgel. The Q&A page says it's sourced from Germany too.
This is a study about Garlic & Allicin reducing TMAO.
Really appreciate your detailed answer. Many thanks.

 


Edited by elc202, 02 June 2026 - 08:28 PM.

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